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Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation
Chen, ST; Wang, JF; Wang, Z; Lin, XP; Zhao, BX; Kaliaperumal, K; Liao, XJ; Tu, ZC; Li, JL; Xu, SH; Liu, YH; txush@jnu.edu.cn; yonghongliu@scsio.ac.cn
2017
Source PublicationFITOTERAPIA
Volume117Pages:71-78
AbstractFive new compounds, including a cytotoxic dimeric isocoumarin, bipenicilisorin (1), a merosesquiterpenoid, yaminterritrem C (2), a citrinin dimer, penicitrinone F (3), a alkaloid, terremide D (4), and a delta-Valerolacton, (E)-4-(propen-1-yl)-5,6-dihydro-2H-pyran-2-one (5), along with ten known compounds (6-15) were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that 1 exhibited significant cytotoxic activities against K562, A549, and Huh-7 cell lines with IC50 values of 6.78, 6.94, and 2.59 mu M, respectively. Compound 3 exhibited moderate inhibitory activity against EV71 with IC50 value of 14.50 mu M. In addition, 13 and 14 showed specific COX-2 inhibitory activities with IC50 values of 1.09 and 1.97 mu M, respectively. (C) 2017 Published by Elsevier B.V.
Department[Chen, Shengtian; Zhao, Bingxin; Liao, Xiaojian; Xu, Shihai] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China; [Chen, Shengtian; Wang, Junfeng; Lin, Xiuping; Kaliaperumal, Kumaravel; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Ecol Guangdong Key Lab Marine Mat Med,RNAM Ctr Ma, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Zhen; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Li, Jianlin] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China; [Liu, Yonghong] South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China
KeywordIsocoumarin Merosesquiterpenoid Citrinin Dimer Alkaloid Cytotoxic Cox-2
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16245
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authortxush@jnu.edu.cn; yonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
Chen, ST,Wang, JF,Wang, Z,et al. Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation[J]. FITOTERAPIA,2017,117:71-78.
APA Chen, ST.,Wang, JF.,Wang, Z.,Lin, XP.,Zhao, BX.,...&yonghongliu@scsio.ac.cn.(2017).Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation.FITOTERAPIA,117,71-78.
MLA Chen, ST,et al."Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation".FITOTERAPIA 117(2017):71-78.
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