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New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum
Bao, J; Wang, J; Zhang, XY; Nong, XH; Qi, SH; shuhuaqi@scsio.ac.cn
2017
Source PublicationCHEMISTRY & BIODIVERSITY
Volume14Issue:3Pages:e1600327-
AbstractSix new compounds including two furanone derivatives sclerotiorumins A and B (1 and 2), one novel oxadiazin derivative sclerotiorumin C (3), one pyrrole derivative 1-(4-benzyl-1H-pyrrol-3-yl)ethanone (4), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin (5) and ferrineohydroxyaspergillin (6) were isolated from the co-culture of marine-derived fungi Aspergillus sclerotiorum and Penicillium citrinum. Compound 3 was the first natural 1,2,4-oxadiazin-6-one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line (IC50=4.2 mu m) and strong toxicity towards brine shrimp (LC50=6.1 mu m), and oppositely increased the growth and biofilm formation of Staphylococcus aureus.
Department[Bao, Jie; Wang, Jie; Zhang, Xiao-Yong; Nong, Xu-Hua; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
KeywordAspergillus Sclerotiorum Furanone Derivatives Complexes Of Neoaspergillic Acid Cytotoxic Activities 1 2 4-oxadiazin-6-one
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16247
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshuhuaqi@scsio.ac.cn
Recommended Citation
GB/T 7714
Bao, J,Wang, J,Zhang, XY,et al. New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum[J]. CHEMISTRY & BIODIVERSITY,2017,14(3):e1600327-.
APA Bao, J,Wang, J,Zhang, XY,Nong, XH,Qi, SH,&shuhuaqi@scsio.ac.cn.(2017).New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum.CHEMISTRY & BIODIVERSITY,14(3),e1600327-.
MLA Bao, J,et al."New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum".CHEMISTRY & BIODIVERSITY 14.3(2017):e1600327-.
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