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Cytochalasin P-1, a new cytochalasin from the marine-derived fungus Xylaria sp SOF11
Chen, ZM; Chen, YC; Huang, HB; Yang, HY; Zhang, WM; Sun, YL; Wen, J; chenzm818@163.com; jw82123@126.com
2017
Source PublicationZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Volume72Issue:3-4Pages:129-132
AbstractA new cytochalasin, named cytochalasin P-1 (1), together with four known analogs (2-5) was isolated from marine-derived fungus Xylaria sp. SOF11 from the South China Sea. The structure of the new compound was elucidated on the basis of MS and NMR (H-1, C-13, HSQC, HMBC, and NOESY) data analyses. Compounds 1-5 were tested for their cytotoxicities against four tumor cell lines (SF-268, MCF-7, NCI-H460, and HepG-2). Compounds 1-5 showed significant cytotoxicity against two tumor cell lines MCF-7 and SF-268, with the IC50 values varying between 0.33 and 4.17 mu M.
Department[Chen, Ziming; Yang, Hongyan] Lingnan Normal Univ, Sch Chem & Chem Engn, 29 Cunjin Rd, Zhanjiang 524048, Peoples R China; [Sun, Yulin; Wen, Jing] Lingnan Normal Univ, Sch Life Sci & Technol, Zhanjiang 524048, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, 100 Cent Xianlie Rd, Guangzhou 510070, Guangdong, Peoples R China; [Huang, Hongbo] CAS Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
KeywordCytochalasin Cytotoxicity Marine-derived Fungus Xylaria Sp
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16248
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorchenzm818@163.com; jw82123@126.com
Recommended Citation
GB/T 7714
Chen, ZM,Chen, YC,Huang, HB,et al. Cytochalasin P-1, a new cytochalasin from the marine-derived fungus Xylaria sp SOF11[J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES,2017,72(3-4):129-132.
APA Chen, ZM.,Chen, YC.,Huang, HB.,Yang, HY.,Zhang, WM.,...&jw82123@126.com.(2017).Cytochalasin P-1, a new cytochalasin from the marine-derived fungus Xylaria sp SOF11.ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES,72(3-4),129-132.
MLA Chen, ZM,et al."Cytochalasin P-1, a new cytochalasin from the marine-derived fungus Xylaria sp SOF11".ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES 72.3-4(2017):129-132.
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