Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp SCSIO 41501
Ma, X; Nong, XH; Ren, Z; Wang, J; Liang, X; Wang, L; Qi, SH; shuhuaqi@scsio.ac.cn
2017
发表期刊TETRAHEDRON LETTERS
卷号58期号:12页码:1151-1155
摘要A new cyclic pentapeptide and three new linear peptides, namely, aspergillipeptides D-G (1-4), were isolated from a culture broth of marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were confirmed by Marfey's method. Compounds 1 and 2 showed evident antiviral activity against herpes simplex virus type 1 (HSV-1) with IC50 values of 9.5 and 19.8 mu M under their non-cytotoxic concentrations against a Vero cell line, respectively, and 1 also had antiviral activity against acyclovir-resistant clinical isolates of HSV-1. (C) 2017 Elsevier Ltd. All rights reserved.
部门归属[Ma, Xuan; Nong, Xu-Hua; Wang, Jie; Liang, Xiao; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bio Resources Sustainable Utilizat, 164 W Xingang Rd, Guangzhou 510301, Peoples R China; [Ma, Xuan; Nong, Xu-Hua; Wang, Jie; Liang, Xiao; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, 164 W Xingang Rd, Guangzhou 510301, Peoples R China; [Ma, Xuan; Nong, Xu-Hua; Wang, Jie; Liang, Xiao; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, 164 W Xingang Rd, Guangzhou 510301, Peoples R China; [Ma, Xuan; Liang, Xiao] Chinese Acad Sci, Beijing 100049, Peoples R China; [Ren, Zhe; Wang, Lu] Guangzhou Jinan Biomed Res & Dev Ctr, Guangzhou 510632, Peoples R China
关键词Gorgonian-derived Fungus ASp.rgillus Sp. Peptide Antiviral
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16254
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
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Ma, X,Nong, XH,Ren, Z,et al. Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp SCSIO 41501[J]. TETRAHEDRON LETTERS,2017,58(12):1151-1155.
APA Ma, X.,Nong, XH.,Ren, Z.,Wang, J.,Liang, X.,...&shuhuaqi@scsio.ac.cn.(2017).Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp SCSIO 41501.TETRAHEDRON LETTERS,58(12),1151-1155.
MLA Ma, X,et al."Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp SCSIO 41501".TETRAHEDRON LETTERS 58.12(2017):1151-1155.
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