Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus
Kong, FD; Ma, QY; Huang, SZ; Wang, P; Wang, JF; Zhou, LM; Yuan, JZ; Dai, HF; Zhao, YX; daihaofu@itbb.org.cn; zhaoyouxing@itbb.org.cn
2017
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号80期号:4页码:1039-1047
摘要Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated one (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penitillinm sp. SCS-KFD09, isolated from a marine worm, Sipunculus nuchis, from Haikou Bay, China., The, structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations. In addition, the X-ray crystal structures and, absolute configurations :of two previously reported tneroterpenoids, chrodrimanins F (9) and A (11), are described for the first time. Compounds 1, 4, and 7 displayed anti-H1N1 activity with IC50 values of-74,, 58, and 34 mu M, respectively, while compound 5 showed, weak inhibitory activity against Staphylococcus atireas with an MIC of 32 mu g/mL.
部门归属[Kong, Fan-Dong; Ma, Qing-Yun; Huang, Sheng-Zhuo; Wang, Pei; Zhou, Li-Man; Yuan, Jing-Zhe; Dai, Hao-Fu; Zhao, You-Xing] Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China; [Wang, Jun-Feng] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16260
专题中科院海洋生物资源可持续利用重点实验室
通讯作者daihaofu@itbb.org.cn; zhaoyouxing@itbb.org.cn
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Kong, FD,Ma, QY,Huang, SZ,et al. Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(4):1039-1047.
APA Kong, FD.,Ma, QY.,Huang, SZ.,Wang, P.,Wang, JF.,...&zhaoyouxing@itbb.org.cn.(2017).Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus.JOURNAL OF NATURAL PRODUCTS,80(4),1039-1047.
MLA Kong, FD,et al."Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus".JOURNAL OF NATURAL PRODUCTS 80.4(2017):1039-1047.
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