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Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089
Gui, C; Zhang, SW; Zhu, XC; Ding, WJ; Huang, HB; Gu, YC; Duan, YW; Ju, JH; jju@scsio.ac.cn
2017
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume80Issue:5Pages:1594-1603
AbstractTwo new spirotetronate aglycones, 22-dehydroxymethyl-kijanolide (1) and 8-hydroxy-22-dehydroxymethyl-kijanolide (2), along with seven new spirotetronate glycosides, microsporanates A-F (3-8) and tetrocarcin P (9), together with three known tetrocarcins [tetrocarcins A (10), B (11), and AC6H (12)], were isolated from fermentation broths of the marine-derived Micromonospora harpali SCSIO GJ089. The structures of 1-9 were elucidated on the basis of 1D and 2D NMR and MS spectroscopic data. Compounds 3-8 feature an alpha,beta-unsaturated carbonyl moiety within their spirotetronate skeletons. Moreover, compounds 3-12 displayed strong to moderate antibacterial activities against Gram with MIC values ranging from 0.016 to 8.0 mu g/mL.
Department[Gui, Chun; Zhang, Shanwen; Ding, Wenjuan; Huang, Hongbo; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Gui, Chun; Zhang, Shanwen; Ding, Wenjuan; Ju, Jianhua] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 110039, Peoples R China; [Zhu, Xiangcheng; Duan, Yanwen] Cent S Univ, Xiangya Int Acad Translat Med, Natl Engn Res Ctr Combinatorial Biosynthesis Drug, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China; [Gu, Yu-Cheng] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16279
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorjju@scsio.ac.cn
Recommended Citation
GB/T 7714
Gui, C,Zhang, SW,Zhu, XC,et al. Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(5):1594-1603.
APA Gui, C.,Zhang, SW.,Zhu, XC.,Ding, WJ.,Huang, HB.,...&jju@scsio.ac.cn.(2017).Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089.JOURNAL OF NATURAL PRODUCTS,80(5),1594-1603.
MLA Gui, C,et al."Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089".JOURNAL OF NATURAL PRODUCTS 80.5(2017):1594-1603.
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