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Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp SCSIO sof101
Luo, MH; Cuo, ZM; Huang, HB; Song, XQ; Sun, AJ; Dang, YJ; Lu, LC; Ju, JH; lulaicq@l63.com; jju@scsio.ac.cn
2017
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume80Issue:5Pages:1668-1673
AbstractEmodacidamides A H (1-8), natural products featuring anthraquinone amino acid conjugates, have been isolated from a marine-derived fungus, Penicillium sp. SCSIO sof101, together with known anthraquinones 9 and 10. The planar structures of 1-8 were elucidated using a combination of NMR spectroscopy and mass spectrometry. The absolute configurations of the amino acid residues were confirmed using Marfey's method and chiral-phase HPLC analyses. Additionally, isolates were evaluated for possible immunomodulatory and cytotoxic activities. Emodacidamides A (1), C (3), D (4), and E (5) cells with IC50 values of 4.1, 5.1, 12, and 5.4 mu M, respectively.
Department[Luo, Minghe; Huang, Hongbo; Sun, Aijun; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 Xingang Rd West, Guangzhou 510301, Guangdong, Peoples R China; [Luo, Minghe; Song, Xianqin; Lu, Laichun] Third Mil Med Univ, Inst Surg Res, Daping Hosp, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China; [Luo, Minghe; Song, Xianqin; Lu, Laichun] Third Mil Med Univ, Coll Pharm, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China; [Cuo, Zhaomeng; Dang, Yongjun] Fudan Univ, Shanghai Med Coll, Key Lab Mol Med, Minist Educ, 130 Dong An Rd, Shanghai 200032, Peoples R China; [Cuo, Zhaomeng; Dang, Yongjun] Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, 130 Dong An Rd, Shanghai 200032, Peoples R China; [Ju, Jianhua] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 10049, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16280
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorlulaicq@l63.com; jju@scsio.ac.cn
Recommended Citation
GB/T 7714
Luo, MH,Cuo, ZM,Huang, HB,et al. Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp SCSIO sof101[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(5):1668-1673.
APA Luo, MH.,Cuo, ZM.,Huang, HB.,Song, XQ.,Sun, AJ.,...&jju@scsio.ac.cn.(2017).Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp SCSIO sof101.JOURNAL OF NATURAL PRODUCTS,80(5),1668-1673.
MLA Luo, MH,et al."Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp SCSIO sof101".JOURNAL OF NATURAL PRODUCTS 80.5(2017):1668-1673.
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