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Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth
Wang, J; Yao, QF; Amin, M; Nong, XH; Zhang, XY; Qi, SH; shuhuaqi@scsio.ac.cn
2017
Source PublicationJOURNAL OF ANTIBIOTICS
Volume70Issue:6Pages:763-770
AbstractPenicillenols (Al, A2, Bl, B2, Cl and C2) were isolated from Aspergillus restrictus DFFSCS006, and could differentially inhibit biofilm formation and eradicate pre-developed biofilms of Candida albicans. Their structure bioactivity relationships suggested that the saturation of hydrocarbon chain at C-8, R-configuration of C-5 and trans-configuration of the double bond between C-5 and C-6 of pyrrolidine-2,4-dione unit were important for their anti-biofilm activities. Penicillenols A2 and B1 slowed the hyphal growth and suppressed the transcripts of hypha specific genes HWP1, ALS1, ALS3, ECE1 and SAP4. Moreover, penicillenols A2 and B1 were found to act synergistically with amphotericin B against C. albicans biofilm formation.
Department[Wang, Jie; Yao, Qi-Feng; Amin, Muhammad; Nong, Xu-Hua; Zhang, Xiao-Yong; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,Key Lab Trop Mar, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Qi, Shu-Hua] South China Sea Bioresource Exploitat & Utilizat, Guangzhou, Guangdong, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16292
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshuhuaqi@scsio.ac.cn
Recommended Citation
GB/T 7714
Wang, J,Yao, QF,Amin, M,et al. Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth[J]. JOURNAL OF ANTIBIOTICS,2017,70(6):763-770.
APA Wang, J.,Yao, QF.,Amin, M.,Nong, XH.,Zhang, XY.,...&shuhuaqi@scsio.ac.cn.(2017).Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth.JOURNAL OF ANTIBIOTICS,70(6),763-770.
MLA Wang, J,et al."Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth".JOURNAL OF ANTIBIOTICS 70.6(2017):763-770.
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