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Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito
Wang, JL; Saha, TT; Zhang, Y; Zhang, CY; Raikhel, AS; alexander.raikhel@ucr.edu
2017
Source PublicationJOURNAL OF BIOLOGICAL CHEMISTRY
Volume292Issue:24Pages:10306-10315
AbstractJuvenile hormone (JH) controls many biological activities in insects, including development, metamorphosis, and reproduction. In the Aedes aegypti mosquito, a vector of dengue, yellow fever, chikungunya, and zika viruses, the metabolic tissue (the fat body, which is an analogue of the vertebrate liver) produces yolk proteins for developing oocytes. JH is important for the fat body to acquire competence for yolk protein production. However, the molecular mechanisms of how JH promotes mosquito reproduction are not completely understood. In this study we show that stimulation of the JH receptor methoprene-tolerant (Met) activates expression of genes encoding the regulator of ribosome synthesis 1 (RRS1) and six ribosomal proteins (two ribosomal large subunit proteins, two ribosomal small subunit proteins, and two mitochondrial ribosomal proteins). Moreover, RNAi-mediated depletion of RRS1 decreased biosynthesis of the ribosomal protein L32 (RpL32). Depletion of Met, RRS1, or RpL32 led to retardation of ovarian growth and reduced mosquito fecundity, which may at least in part have resulted from decreased vitellogenin protein production in the fat body. In summary, our results indicate that JH is critical for inducing the expression of ribosomal protein genes and demonstrate that RRS1 mediates the JH signal to enhance both ribosomal biogenesis and vitellogenesis.
Department[Wang, Jia-Lin; Saha, Tusar T.; Zhang, Yang; Zhang, Changyu; Raikhel, Alexander S.] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA; [Wang, Jia-Lin] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China; [Saha, Tusar T.; Raikhel, Alexander S.] Univ Calif Riverside, Inst Integrat Genom Biol, Riverside, CA 92521 USA; [Zhang, Yang] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Changyu] Guizhou Univ, Coll Agr, Guizhou Key Lab Plant Pest Management Mt Reg, Guiyang 550025, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16293
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoralexander.raikhel@ucr.edu
Recommended Citation
GB/T 7714
Wang, JL,Saha, TT,Zhang, Y,et al. Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2017,292(24):10306-10315.
APA Wang, JL,Saha, TT,Zhang, Y,Zhang, CY,Raikhel, AS,&alexander.raikhel@ucr.edu.(2017).Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito.JOURNAL OF BIOLOGICAL CHEMISTRY,292(24),10306-10315.
MLA Wang, JL,et al."Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito".JOURNAL OF BIOLOGICAL CHEMISTRY 292.24(2017):10306-10315.
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