Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis
Wang, JF; He, WJ; Kong, FD; Tian, XP; Wang, P; Zhou, XJ; Liu, YH; gale9888@163.com; yonghongliu@scsio.ac.cn
2017
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号80期号:6页码:1725-1733
摘要Nine new humulane-derived sesquiterpenoids, ochracenes A-I (1-9), were isolated from the Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702. Their structures including absolute configurations were elucidated on the basis of spectroscopic analysis, Mosher's method, and electronic circular dichroism analysis. Compared with previous humulane-type sesquiterpenoids, ochracenes A-I (1-9) featured novel carbon skeletons with corresponding methyl migration, ring cleavage, and carbon loss. Two unprecedented 8,9-secocyclic sesquiterpenoids (2 and 3) exhibited inhibitory effects on lipopolysaccharide-induced NO release in RAW 264.7 mouse macrophage cell lines with IC50 values of 14.6 +/- 0.5 and 18.3 +/- 1.7 mu M, respectively.
部门归属[Wang, Junfeng; He, Weijun; Tian, Xinpeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China; [He, Weijun; Zhou, Xiaojiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China; [Kong, Fandong; Wang, Pei] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16295
专题中科院海洋生物资源可持续利用重点实验室
通讯作者gale9888@163.com; yonghongliu@scsio.ac.cn
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Wang, JF,He, WJ,Kong, FD,et al. Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1725-1733.
APA Wang, JF.,He, WJ.,Kong, FD.,Tian, XP.,Wang, P.,...&yonghongliu@scsio.ac.cn.(2017).Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis.JOURNAL OF NATURAL PRODUCTS,80(6),1725-1733.
MLA Wang, JF,et al."Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis".JOURNAL OF NATURAL PRODUCTS 80.6(2017):1725-1733.
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