SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis
Wang, JF; He, WJ; Kong, FD; Tian, XP; Wang, P; Zhou, XJ; Liu, YH; gale9888@163.com; yonghongliu@scsio.ac.cn
2017
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume80Issue:6Pages:1725-1733
AbstractNine new humulane-derived sesquiterpenoids, ochracenes A-I (1-9), were isolated from the Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702. Their structures including absolute configurations were elucidated on the basis of spectroscopic analysis, Mosher's method, and electronic circular dichroism analysis. Compared with previous humulane-type sesquiterpenoids, ochracenes A-I (1-9) featured novel carbon skeletons with corresponding methyl migration, ring cleavage, and carbon loss. Two unprecedented 8,9-secocyclic sesquiterpenoids (2 and 3) exhibited inhibitory effects on lipopolysaccharide-induced NO release in RAW 264.7 mouse macrophage cell lines with IC50 values of 14.6 +/- 0.5 and 18.3 +/- 1.7 mu M, respectively.
Department[Wang, Junfeng; He, Weijun; Tian, Xinpeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China; [He, Weijun; Zhou, Xiaojiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China; [Kong, Fandong; Wang, Pei] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16295
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorgale9888@163.com; yonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
Wang, JF,He, WJ,Kong, FD,et al. Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1725-1733.
APA Wang, JF.,He, WJ.,Kong, FD.,Tian, XP.,Wang, P.,...&yonghongliu@scsio.ac.cn.(2017).Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis.JOURNAL OF NATURAL PRODUCTS,80(6),1725-1733.
MLA Wang, JF,et al."Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis".JOURNAL OF NATURAL PRODUCTS 80.6(2017):1725-1733.
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