Screening of Anti-Biofilm Compounds from Marine-Derived Fungi and the Effects of Secalonic Acid D on Staphylococcus aureus Biofilm
Wang, J; Nong, XH; Zhang, XY; Xu, XY; Amin, M; Qi, SH; shuhuaqi@scsio.ac.cn
2017
发表期刊JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
卷号27期号:6页码:1078-1089
摘要Biofilm formation of Staphylococcus aureus is one of its mechanisms of drug resistance. Anti-biofilm screening of 106 compounds from marine-derived fungi displayed that 12 compounds inhibited S. aureus biofilm formation by > 50% at the concentration of 100 mu g/ml, and only secalonic acid D (SAD) and B inhibited by > 90% at 6.25 mu g/ml without inhibiting cell growth after 24-h incubation. Meanwhile, it was found that the double bond between C-1 and C-10 of citrinin derivatives and the C-C connection position of two chromone monomers may be important for their anti-biofilm activities. Moreover, SAD slightly facilitated biofilm eradication and influenced its architecture. Furthermore, SAD slowed the cell growth rate in the preceding 18-h incubation and differentially regulated transcriptional expression of several genes, such as agr, isaA, icaA, and icaD, associated with biofilm formation in planktonic and biofilm cells, which may be the reason for the anti-biofilm activity of SAD. Finally, SAD acted synergistically against S. aureus growth and biofilm formation with other antibiotics. These findings indicated that various natural products from marine-derived fungi, such as SAD, could be used as a potential biofilm inhibitor against S. aureus.
部门归属[Wang, Jie; Nong, Xu-Hua; Zhang, Xiao-Yong; Xu, Xin-Ya; Amin, Muhammad; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China; [Qi, Shu-Hua] South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Anti-biofilm Activity Staphylococcus Aureus Marine Natural Product Secalonic Acid d Mechanism Of Action
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16296
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
推荐引用方式
GB/T 7714
Wang, J,Nong, XH,Zhang, XY,et al. Screening of Anti-Biofilm Compounds from Marine-Derived Fungi and the Effects of Secalonic Acid D on Staphylococcus aureus Biofilm[J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2017,27(6):1078-1089.
APA Wang, J.,Nong, XH.,Zhang, XY.,Xu, XY.,Amin, M.,...&shuhuaqi@scsio.ac.cn.(2017).Screening of Anti-Biofilm Compounds from Marine-Derived Fungi and the Effects of Secalonic Acid D on Staphylococcus aureus Biofilm.JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,27(6),1078-1089.
MLA Wang, J,et al."Screening of Anti-Biofilm Compounds from Marine-Derived Fungi and the Effects of Secalonic Acid D on Staphylococcus aureus Biofilm".JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 27.6(2017):1078-1089.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
JOURNAL OF MICROBIOL(4069KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。