Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020
Liang, X; Nong, XH; Huang, ZH; Qi, SH; shuhuaqi@scsio.ac.cn
2017
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号65期号:25页码:5114-5121
摘要A new linear peptide simplicilliumtide I (1) and four new cyclic peptides simplicilliumtides JM (25) together with known analogues verlamelins A and B (6 and 7) were isolated from the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were further confirmed by chemical structural modification, Marfeys and Moshers methods. Compounds 2, 6, and 7 showed significant antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also had obvious antiviral activity toward HSV-1 with IC50 values of 14.0, 16.7, and 15.6 mu M, respectively. The structurebioactivity relationship of this type of cyclic peptide was also discussed. This is the first time to discuss the effects of the lactone linkage and the substituent group of the fatty acid chain fragment on the bioactivity of this type of cyclic peptides. This is also the first time to report the antiviral activity of these cyclic peptides.
部门归属[Liang, Xiao; Nong, Xu-Hua; Huang, Zhong-Hui; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Liang, Xiao; Huang, Zhong-Hui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
关键词Deep-sea-derived Fungus Simplicillium Obclavatum Peptide Antifungal Antiviral Structure-bioactivity Relationship
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16299
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
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GB/T 7714
Liang, X,Nong, XH,Huang, ZH,et al. Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(25):5114-5121.
APA Liang, X,Nong, XH,Huang, ZH,Qi, SH,&shuhuaqi@scsio.ac.cn.(2017).Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,65(25),5114-5121.
MLA Liang, X,et al."Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.25(2017):5114-5121.
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