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Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089
Jiang, XD; Zhang, QB; Zhu, YG; Nie, FL; Wu, ZC; Yang, CF; Zhang, LP; Tian, XP; Zhang, CS; czhang2006@gmail.com
2017
Source PublicationTETRAHEDRON
Volume73Issue:26Pages:3585-3590
AbstractBenzofluorene-containing angucyclines, such as lomaiviticins, kinamycins, and fluostatins, have attracted increasing attentions on chemical synthesis and biosynthesis due to their unique structures and potent biological activities. Our continuous searching for novel natural products from deep-sea derived actinomycetes led to the discovery of nenestatin A (1), a benzo[b]fluorene compound possessing a carbon scaffold similar to the monomeric lomaiviticins, from the deep sea-derived Micromonospora echinospora SCSIO 04089. In addition, the biosynthetic gene cluster of nenestatin A (nes) was identified by a genome sequencing approach and comparative bioinformatics analysis with the lomaiviticin biosynthetic gene clusters. The nes-gene cluster was further verified by in vivo gene disruption experiments to afford a biosynthetic intermediate homo-dehydrorabelomycin E (2). This study adds a new member to the growing family of benzofluorene angucyclines and paves the way for further biosynthetic investigations. (C) 2017 Elsevier Ltd. All rights reserved.
Department[Jiang, Xiaodong; Zhang, Qingbo; Zhu, Yiguang; Nie, Fangling; Wu, Zhengchao; Yang, Chunfang; Zhang, Liping; Tian, Xinpeng; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Jiang, Xiaodong; Nie, Fangling] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
KeywordMarine Actinomycetes Benzofluorene Biosynthesis Natural Products Nenestatin a
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16300
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorczhang2006@gmail.com
Recommended Citation
GB/T 7714
Jiang, XD,Zhang, QB,Zhu, YG,et al. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089[J]. TETRAHEDRON,2017,73(26):3585-3590.
APA Jiang, XD.,Zhang, QB.,Zhu, YG.,Nie, FL.,Wu, ZC.,...&czhang2006@gmail.com.(2017).Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089.TETRAHEDRON,73(26),3585-3590.
MLA Jiang, XD,et al."Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089".TETRAHEDRON 73.26(2017):3585-3590.
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