Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089
Jiang, XD; Zhang, QB; Zhu, YG; Nie, FL; Wu, ZC; Yang, CF; Zhang, LP; Tian, XP; Zhang, CS; czhang2006@gmail.com
2017
发表期刊TETRAHEDRON
卷号73期号:26页码:3585-3590
摘要Benzofluorene-containing angucyclines, such as lomaiviticins, kinamycins, and fluostatins, have attracted increasing attentions on chemical synthesis and biosynthesis due to their unique structures and potent biological activities. Our continuous searching for novel natural products from deep-sea derived actinomycetes led to the discovery of nenestatin A (1), a benzo[b]fluorene compound possessing a carbon scaffold similar to the monomeric lomaiviticins, from the deep sea-derived Micromonospora echinospora SCSIO 04089. In addition, the biosynthetic gene cluster of nenestatin A (nes) was identified by a genome sequencing approach and comparative bioinformatics analysis with the lomaiviticin biosynthetic gene clusters. The nes-gene cluster was further verified by in vivo gene disruption experiments to afford a biosynthetic intermediate homo-dehydrorabelomycin E (2). This study adds a new member to the growing family of benzofluorene angucyclines and paves the way for further biosynthetic investigations. (C) 2017 Elsevier Ltd. All rights reserved.
部门归属[Jiang, Xiaodong; Zhang, Qingbo; Zhu, Yiguang; Nie, Fangling; Wu, Zhengchao; Yang, Chunfang; Zhang, Liping; Tian, Xinpeng; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Jiang, Xiaodong; Nie, Fangling] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
关键词Marine Actinomycetes Benzofluorene Biosynthesis Natural Products Nenestatin a
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16300
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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GB/T 7714
Jiang, XD,Zhang, QB,Zhu, YG,et al. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089[J]. TETRAHEDRON,2017,73(26):3585-3590.
APA Jiang, XD.,Zhang, QB.,Zhu, YG.,Nie, FL.,Wu, ZC.,...&czhang2006@gmail.com.(2017).Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089.TETRAHEDRON,73(26),3585-3590.
MLA Jiang, XD,et al."Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089".TETRAHEDRON 73.26(2017):3585-3590.
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