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Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32
Zhu, XC; Duan, YW; Cui, ZM; Wang, Z; Li, ZX; Zhang, Y; Ju, JH; Huang, HB; huanghb@scsio.ac.cn
2017
Source PublicationJOURNAL OF ANTIBIOTICS
Volume70Issue:7Pages:819-822
AbstractTwo new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A(1), 3), saquayamycin B (4) and vineomycin B-2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2-5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 mu M, respectively.
Department[Zhu, Xiangcheng; Duan, Yanwen] Cent S Univ, Xianga Int Acad Translat Med, Natl Engn Res Ctr Combinatorial Biosynth Drug Dis, Changsha, Peoples R China; [Cui, Zhaomeng; Wang, Zhen; Li, Zengxia] Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Key Lab Metab & Mol Med,Minist Educ, Shanghai, Peoples R China; [Zhang, Yun; Ju, Jianhua; Huang, Hongbo] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16303
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorhuanghb@scsio.ac.cn
Recommended Citation
GB/T 7714
Zhu, XC,Duan, YW,Cui, ZM,et al. Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32[J]. JOURNAL OF ANTIBIOTICS,2017,70(7):819-822.
APA Zhu, XC.,Duan, YW.,Cui, ZM.,Wang, Z.,Li, ZX.,...&huanghb@scsio.ac.cn.(2017).Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32.JOURNAL OF ANTIBIOTICS,70(7),819-822.
MLA Zhu, XC,et al."Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32".JOURNAL OF ANTIBIOTICS 70.7(2017):819-822.
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