Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities
Luo, XW; Yang, J; Chen, FM; Lin, XP; Chen, CM; Zhou, XF; Liu, SW; Liu, YH; xfzhou@scsio.ac.cn; liusw@smu.edu.cn; yonghongliu@scsio.ac.cn
2018
发表期刊FRONTIERS IN CHEMISTRY
卷号6页码:-282
摘要Influenza A virus (IAV) is a severe worldwide threat to public health and economic development due to its high morbidity and mortality. Marine-derived fungi have been evidenced as a prolific source for the discovery of pharmacologically-active lead compounds. During the course of our search for novel bioactive substances from marine microorganisms, six new polyketides, including two octaketides (1-2), one chromone derivative (13), two highly substituted phthalides (17-18), and one alpha-pyrone derivative (21) along with 22 known congeners were isolated from a mangrove-associated fungus Diaporthe sp. SCSIO 41011. Their structures were determined by spectroscopic analysis and by comparison with literature data. And the absolute configurations were established according to the specific rotation or electron circular dichroism method. Antiviral evaluation results revealed that compounds 14, 15, 26, and 5-chloroisorotiorin displayed significant anti-IAV activities against three influenza A virus subtypes, including A/Puerto Rico/8/34 H274Y (H1N1), A/FM-1/1/47 (H1N1), and A/Aichi/2/68 (H3N2), with IC50 values in the range of 2.52-39.97 mu M. The preliminary structure-activity relationships (SARs) are also discussed. These findings expand the chemical and bioactive diversity of polyketides derived from the genus Diaporthe, and also provide a basis for further development and utilization of chromone, xanthone, and chloroazaphilone derivatives as source of potential anti-viral chemotherapy agents.
部门归属[Luo, Xiaowei; Lin, Xiuping; Chen, Chunmei; Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou, Guangdong, Peoples R China; [Luo, Xiaowei; Chen, Chunmei; Zhou, Xuefeng; Liu, Yonghong] Univ Chinese Acad Sci, Beijing, Peoples R China; [Yang, Jie; Chen, Feimin; Liu, Shuwen] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangzhou, Guangdong, Peoples R China; [Liu, Shuwen] Southern Med Univ, State Key Lab Organ Failure Res, Guangzhou, Guangdong, Peoples R China
学科领域Chemistry
关键词[WOS]Diaporthe sp ; polyketides ; cytosporones ; phthalides ; anti-influenza A virus
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16922
专题中科院海洋生物资源可持续利用重点实验室
通讯作者xfzhou@scsio.ac.cn; liusw@smu.edu.cn; yonghongliu@scsio.ac.cn
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Luo, XW,Yang, J,Chen, FM,et al. Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities[J]. FRONTIERS IN CHEMISTRY,2018,6:-282.
APA Luo, XW.,Yang, J.,Chen, FM.,Lin, XP.,Chen, CM.,...&yonghongliu@scsio.ac.cn.(2018).Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities.FRONTIERS IN CHEMISTRY,6,-282.
MLA Luo, XW,et al."Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities".FRONTIERS IN CHEMISTRY 6(2018):-282.
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