Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol
Liao, SR; Porta, A; Cheng, XP; Ma, X; Zanoni, G; Zhang, LM; gz@unipv.it; zhang@chem.ucsb.edu
2018
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号57期号:27页码:8250-8254
摘要Using the previously designed biphenyl-2-ylphosphine ligand, featuring a remote tertiary amino group, the first gold-catalyzed intermolecular hydroalkenylation of alkynes has been developed. Synthetically valuable conjugated dienyl alcohols are formed in moderate to good yields. A range of alkenyltrifluoroborates are allowed as the alkenyl donor, and no erosion of alkene geometry and/or the propargylic configuration are detected. DFT calculations confirm the critical role of the remote basic group in the ligand as a general-base catalyst for promoting this novel gold catalysis with good efficiency.
部门归属[Liao, Shengrong] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China; [Liao, Shengrong; Cheng, Xinpeng; Ma, Xu; Zhang, Liming] UCSB, Dept Chem & Biochem, Santa Barbara, CA 93106 USA; [Porta, Alessio; Zanoni, Giuseppe] Univ Pavia, Dept Chem, Viale Taramelli,10, I-27100 Pavia, Italy
学科领域Chemistry
关键词[WOS]conjugation ; gold ; ligand design ; reaction mechanisms ; synthetic methods
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16923
专题中科院海洋生物资源可持续利用重点实验室
通讯作者gz@unipv.it; zhang@chem.ucsb.edu
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GB/T 7714
Liao, SR,Porta, A,Cheng, XP,et al. Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(27):8250-8254.
APA Liao, SR.,Porta, A.,Cheng, XP.,Ma, X.,Zanoni, G.,...&zhang@chem.ucsb.edu.(2018).Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(27),8250-8254.
MLA Liao, SR,et al."Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.27(2018):8250-8254.
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