SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure
Chen, LZ; Zhang, W; Guo, ZQ; Zhang, L; zhangli@scsio.ac.cn
2018
Source PublicationENVIRONMENTAL POLLUTION
Volume238Pages:17-25
AbstractFish can acclimate to chronic arsenic (As) exposure, but the mechanisms of acclimation remain unclear to date. Therefore, this study conducted 28-d chronic inorganic As [As(III) and As(V)I exposures in fresh-water medaka (Oryzias mekongensis), examined the As bioaccumulation and biotransformation during exposure, and the As acute toxicity and toxicokinetics after exposure. After chronic As(V) exposure, the 96-h lethal concentration (96-h LC50) of As(V) increased 1.3-fold (from 223 to 286 mu mol/L), indicating that the fish became more tolerant to As(V). The As bioaccumulation in As(V)-exposed fish increased gradually during the initial 21-d exposure period and then decreased at 28 d, indicating that acclimation occurred to regulate the total As levels. Toxicokinetics measurement suggested that As(V) uptake (uptake rate constant, k(u)) was significantly decreased and As(III) elimination (efflux rate constant, k(e1)) was significantly increased, both of which could reduce As bioaccumulation. Furthermore, the organic As species became more predominant (50.1-69.3%) in exposed fish, while the inorganic As species were predominant (53.6-56.4%) in the control fish, suggesting that the capability of As biotransformation increased to acclimate inorganic As during chronic exposure. In summary, this study elucidated the acclimation strategies (reduced bioaccumulation and increased biotransformation) of O. mekongensis to counter the ambient As contamination. (C) 2018 Elsevier Ltd. All rights reserved.
Department[Chen, Lizhao; Zhang, Wei; Zhang, Li] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Lizhao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Guo, Zhiqiang] Hainan Univ, Coll Oceanol, State Key Lab Marine Resource Utilizat South Chin, Haikou 570228, Hainan, Peoples R China
Subject AreaEnvironmental Sciences & Ecology
WOS KeywordArsenic ; Acclimation ; Bioaccumulation ; Biotransformation ; Freshwater fish
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16926
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorzhangli@scsio.ac.cn
Recommended Citation
GB/T 7714
Chen, LZ,Zhang, W,Guo, ZQ,et al. Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure[J]. ENVIRONMENTAL POLLUTION,2018,238:17-25.
APA Chen, LZ,Zhang, W,Guo, ZQ,Zhang, L,&zhangli@scsio.ac.cn.(2018).Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure.ENVIRONMENTAL POLLUTION,238,17-25.
MLA Chen, LZ,et al."Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure".ENVIRONMENTAL POLLUTION 238(2018):17-25.
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