Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure
Chen, LZ; Zhang, W; Guo, ZQ; Zhang, L; zhangli@scsio.ac.cn
2018
发表期刊ENVIRONMENTAL POLLUTION
卷号238页码:17-25
摘要Fish can acclimate to chronic arsenic (As) exposure, but the mechanisms of acclimation remain unclear to date. Therefore, this study conducted 28-d chronic inorganic As [As(III) and As(V)I exposures in fresh-water medaka (Oryzias mekongensis), examined the As bioaccumulation and biotransformation during exposure, and the As acute toxicity and toxicokinetics after exposure. After chronic As(V) exposure, the 96-h lethal concentration (96-h LC50) of As(V) increased 1.3-fold (from 223 to 286 mu mol/L), indicating that the fish became more tolerant to As(V). The As bioaccumulation in As(V)-exposed fish increased gradually during the initial 21-d exposure period and then decreased at 28 d, indicating that acclimation occurred to regulate the total As levels. Toxicokinetics measurement suggested that As(V) uptake (uptake rate constant, k(u)) was significantly decreased and As(III) elimination (efflux rate constant, k(e1)) was significantly increased, both of which could reduce As bioaccumulation. Furthermore, the organic As species became more predominant (50.1-69.3%) in exposed fish, while the inorganic As species were predominant (53.6-56.4%) in the control fish, suggesting that the capability of As biotransformation increased to acclimate inorganic As during chronic exposure. In summary, this study elucidated the acclimation strategies (reduced bioaccumulation and increased biotransformation) of O. mekongensis to counter the ambient As contamination. (C) 2018 Elsevier Ltd. All rights reserved.
部门归属[Chen, Lizhao; Zhang, Wei; Zhang, Li] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Lizhao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Guo, Zhiqiang] Hainan Univ, Coll Oceanol, State Key Lab Marine Resource Utilizat South Chin, Haikou 570228, Hainan, Peoples R China
学科领域Environmental Sciences & Ecology
关键词[WOS]Arsenic ; Acclimation ; Bioaccumulation ; Biotransformation ; Freshwater fish
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16926
专题中科院海洋生物资源可持续利用重点实验室
通讯作者zhangli@scsio.ac.cn
推荐引用方式
GB/T 7714
Chen, LZ,Zhang, W,Guo, ZQ,et al. Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure[J]. ENVIRONMENTAL POLLUTION,2018,238:17-25.
APA Chen, LZ,Zhang, W,Guo, ZQ,Zhang, L,&zhangli@scsio.ac.cn.(2018).Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure.ENVIRONMENTAL POLLUTION,238,17-25.
MLA Chen, LZ,et al."Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure".ENVIRONMENTAL POLLUTION 238(2018):17-25.
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