Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus
Zhu, MY; Wang, LJ; Zhang, QB; Ali, M; Zhu, SQ; Yu, PQ; Gu, XF; Zhang, HB; Zhu, YG; He, J; hejingjj@mail.hzau.edu
2018
发表期刊ORGANIC LETTERS
卷号20期号:12页码:3562-3565
摘要The biosynthetic pathway of diisonitrile chalkophore SF2768 was identified in Streptomyces thioluteus through heterologous expression recently. Isolation and structure elucidation of the N-substituted formamides that coexisted with the diisonitriles implied that a hydration event was involved. In vitro enzymatic assays of an endogenous isonitrile hydratase suggested a rare sequential-hydration of the diisonitriles. Additionally, the results of Cu-CAS assays indicate that both partial and complete hydration led to the loss of the copper-chelating ability of SF2768.
部门归属[Zhu, Mengyi; Wang, Lijuan; Ali, Muhammad; Zhu, Siqi; Yu, Peiqing; Gu, Xiaofei; He, Jing] Huazhong Agr Univ, Coll Life Sci & Technol, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China; [Wang, Lijuan; Zhang, Haibo] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Ali, Muhammad] COMSATS Univ Islamabad, Dept Environm Sci, Biotechnol Program, Abbottabad campus, Abbottabad, Pakistan
学科领域Chemistry
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16928
专题中科院海洋生物资源可持续利用重点实验室
通讯作者hejingjj@mail.hzau.edu
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Zhu, MY,Wang, LJ,Zhang, QB,et al. Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus[J]. ORGANIC LETTERS,2018,20(12):3562-3565.
APA Zhu, MY.,Wang, LJ.,Zhang, QB.,Ali, M.,Zhu, SQ.,...&hejingjj@mail.hzau.edu.(2018).Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus.ORGANIC LETTERS,20(12),3562-3565.
MLA Zhu, MY,et al."Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus".ORGANIC LETTERS 20.12(2018):3562-3565.
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