Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering
Li, Y; Zhang, CY; Liu, CX; Ju, JH; Ma, JY; jju@scsio.ac.cn; majunying@scsio.ac.cn
2018
发表期刊FRONTIERS IN MICROBIOLOGY
卷号9页码:-1269
摘要The Actinomycetes are metabolically flexible microorganisms capable of producing a wide range of interesting compounds, including but by no means limited to, siderophores which have high affinity for ferric iron. In this study, we report the complete genome sequence of marine-derived Streptomyces atratus ZH16 and the activation of an embedded siderophore gene cluster via the application of metabolic engineering methods. The S. atratus ZH16 genome reveals that this strain has the potential to produce 26 categories of natural products (NPs) barring the ilamycins. Our activation studies revealed S. atratus SCSIO ZH16 to be a promising source of the production of nocardamine-type (desferrioxamine) compounds which are important in treating acute iron intoxication and performing ecological remediation. We conclude that metabolic engineering provides a highly effective strategy by which to discover drug-like compounds and new NPs in the genomic era.
部门归属[Li, Yan; Zhang, Chunyan; Ju, Jianhua; Ma, Junying] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou, Guangdong, Peoples R China; [Li, Yan; Zhang, Chunyan; Ju, Jianhua; Ma, Junying] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China; [Liu, Chengxiong] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang, Peoples R China
学科领域Microbiology
关键词[WOS]Streptomyces atratus ZH16 ; in-frame deletion ; metabolic engineering ; siderophore ; nocardamine
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16929
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn; majunying@scsio.ac.cn
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GB/T 7714
Li, Y,Zhang, CY,Liu, CX,et al. Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering[J]. FRONTIERS IN MICROBIOLOGY,2018,9:-1269.
APA Li, Y.,Zhang, CY.,Liu, CX.,Ju, JH.,Ma, JY.,...&majunying@scsio.ac.cn.(2018).Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering.FRONTIERS IN MICROBIOLOGY,9,-1269.
MLA Li, Y,et al."Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering".FRONTIERS IN MICROBIOLOGY 9(2018):-1269.
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