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Activated production of silent metabolites from marine-derived fungus Penicillium citrinum
Gu, YQ; Ding, PY; Liang, ZP; Song, Y; Liu, YH; Chen, GT; Li, JL; guangtong_chen@ntu.edu.cn; jianlinli1980@163.com
2018
Source PublicationFITOTERAPIA
Volume127Pages:207-211
AbstractAs an attempt to utilize of rare earth elements as a novel method to activate the silent genes in fungus, the marine-derived fungus Penicillitan citrinum was cultured under ordinary laboratory fermentation conditions in the presence of scandium chloride (ScCl3, 50 mu M), and chemical investigation led to the isolation and characterization of three new peptide derivatives (1-3), along with four known pyrrolidine alkaloids (4-7). Those structures were elucidated by spectroscopic data interpretation, as well as chemical reactions. Comparative metabolic profiling of the culture extracts (with/without scandium chloride) indicated that compounds 1-3 scarcely detected in the absence of ScCl3. In addition, the antibacterial and cytotoxic activities of all isolated products were evaluated.
Department[Gu, Yuqin; Ding, Peiyu; Song, Yan; Chen, Guangtong; Li, Jian Lin] Nantong Univ, Sch Pharm, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China; [Liang, Zhipeng] Nantong Univ, Dept Anal & Testing Ctr, Nantong 226001, Peoples R China; [Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
Subject AreaPharmacology & Pharmacy
WOS KeywordPenicillium citrinum ; Scandium chloride treated cultures ; Activated production of silent metabolites ; Antibacterial activity ; Cytotoxic activity
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16934
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorguangtong_chen@ntu.edu.cn; jianlinli1980@163.com
Recommended Citation
GB/T 7714		 Gu, YQ,Ding, PY,Liang, ZP,et al. Activated production of silent metabolites from marine-derived fungus Penicillium citrinum[J]. FITOTERAPIA,2018,127:207-211.
APA Gu, YQ.,Ding, PY.,Liang, ZP.,Song, Y.,Liu, YH.,...&jianlinli1980@163.com.(2018).Activated production of silent metabolites from marine-derived fungus Penicillium citrinum.FITOTERAPIA,127,207-211.
MLA Gu, YQ,et al."Activated production of silent metabolites from marine-derived fungus Penicillium citrinum".FITOTERAPIA 127(2018):207-211.
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