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New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025
Huang, ZH; Nong, XH; Liang, X; Qi, SH; shuhuaqi@scsio.ac.cn
2018
Source PublicationTETRAHEDRON
Volume74Issue:21Pages:2620-2626
AbstractEight new tetramic acid derivatives, cladosporiumins A-H (1-8) were isolated from a culture broth of Cladosporium sp. SCSIO z0025 derived from the deep-sea sediment collected from Okinawa Trough. Their structures were elucidated by extensive spectroscopic data analysis. Compounds 1-3 were unique 3acyltetramic acids with a hexyl enic alcohol side chain and a six-membered lactone ring substituted at C-3 of the 2, 4-pyrrolidinedione skeleton. The absolute configurations of chiral carbons of the 2, 4pyrrolidinedione unit in 1-4 and 7 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. And the absolute configurations of chiral carbons of the sixmembered lactone ring in 1-3 were established by density functional theory calculation of their C-13 NMR chemical shifts. In addition, all the compounds were tested for cytotoxic, antibacterial, anti-biofilm, and AchE inhibitory activities. (C) 2018 Elsevier Ltd. All(C)rights reserved.
Department[Huang, Zhong-hui; Nong, Xu-hua; Liang, Xiao; Qi, Shu-hua] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Huang, Zhong-hui; Liang, Xiao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Subject AreaChemistry
WOS KeywordDeep-sea fungus ; Cladosporium sp SCSIO Z0025 ; Tetramic acid derivatives ; Quantum chemical calculations
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16946
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshuhuaqi@scsio.ac.cn
Recommended Citation
GB/T 7714
Huang, ZH,Nong, XH,Liang, X,et al. New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025[J]. TETRAHEDRON,2018,74(21):2620-2626.
APA Huang, ZH,Nong, XH,Liang, X,Qi, SH,&shuhuaqi@scsio.ac.cn.(2018).New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025.TETRAHEDRON,74(21),2620-2626.
MLA Huang, ZH,et al."New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025".TETRAHEDRON 74.21(2018):2620-2626.
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