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Antimalarial Activity of Plant Metabolites
Pan, WH; Xu, XY; Shi, N; Tsang, SW; Zhang, HJ;;;;;
AbstractMalaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled Antimalarial activity of plant metabolites by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.
Department[Pan, Wen-Hui; Xu, Xin-Ya; Shi, Ni; Tsang, Siu Wai; Zhang, Hong-Jie] Hong Kong Baptist Univ, Sch Chinese Med, 7 Baptist Univ Rd, Kowloon, Hong Kong, Peoples R China; [Xu, Xin-Ya] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, South China Sea Inst Oceanol, Guangzhou 510070, Guangdong, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Chemistry
WOS Keywordanti-malaria activity ; plants ; natural products ; ethnopharmacology ; Plasmodium parasites
Funding ProjectLMB
Document Type期刊论文
Recommended Citation
GB/T 7714
Pan, WH,Xu, XY,Shi, N,et al. Antimalarial Activity of Plant Metabolites[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(5):-1382.
APA Pan, WH.,Xu, XY.,Shi, N.,Tsang, SW.,Zhang, HJ.,...& Activity of Plant Metabolites.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(5),-1382.
MLA Pan, WH,et al."Antimalarial Activity of Plant Metabolites".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.5(2018):-1382.
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