Antimalarial Activity of Plant Metabolites
Pan, WH; Xu, XY; Shi, N; Tsang, SW; Zhang, HJ; 13480448@life.hkbu.edu.hk; xuxinya@scsio.ac.cn; 14252252@life.hkbu.edu.hk; tsang@hkbu.edu.hk; zhanghj@hkbu.edu.hk
2018
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号19期号:5页码:-1382
摘要Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled Antimalarial activity of plant metabolites by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.
部门归属[Pan, Wen-Hui; Xu, Xin-Ya; Shi, Ni; Tsang, Siu Wai; Zhang, Hong-Jie] Hong Kong Baptist Univ, Sch Chinese Med, 7 Baptist Univ Rd, Kowloon, Hong Kong, Peoples R China; [Xu, Xin-Ya] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, South China Sea Inst Oceanol, Guangzhou 510070, Guangdong, Peoples R China
学科领域Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]anti-malaria activity ; plants ; natural products ; ethnopharmacology ; Plasmodium parasites
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16950
专题中科院海洋生物资源可持续利用重点实验室
通讯作者13480448@life.hkbu.edu.hk; xuxinya@scsio.ac.cn; 14252252@life.hkbu.edu.hk; tsang@hkbu.edu.hk; zhanghj@hkbu.edu.hk
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Pan, WH,Xu, XY,Shi, N,et al. Antimalarial Activity of Plant Metabolites[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(5):-1382.
APA Pan, WH.,Xu, XY.,Shi, N.,Tsang, SW.,Zhang, HJ.,...&zhanghj@hkbu.edu.hk.(2018).Antimalarial Activity of Plant Metabolites.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(5),-1382.
MLA Pan, WH,et al."Antimalarial Activity of Plant Metabolites".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.5(2018):-1382.
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