Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008
Bao, J; Zhai, HJ; Zhu, KK; Yu, JH; Zhang, YY; Wang, YY; Jiang, CS; Zhang, XY; Zhang, Y; Zhang, H; bio_baoj@ujn.edu.cn; zhai18363005528@163.com; hkhhh.k@163.com; yujinhai12@sina.com; zhangyun@scsio.ac.cn; bio_wangyy@ujn.edu.cn; jiangchengshi-20@163.com; zhangxiaoyong@scau.edu.cn; bio_zhangh@ujn.edu.cn
2018
发表期刊MARINE DRUGS
卷号16期号:5页码:-174
摘要Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D-K (1-8), along with two known analogues apiosporamide (9) and arthpyrone B (10), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods with that of 1 being established by chemical transformation and X-ray diffraction analysis. Compounds 1 and 2 bore an ester functionality linking the pyridone and decalin moieties first reported in this class of metabolites, while 3 and 4 incorporated a rare natural hexa- or tetrahydrobenzofuro[3,2-c]pyridin-3(2H)-one motif. Compounds 3-6 and 9 exhibited moderate to significant antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus with IC50 values ranging from 1.66-42.8 M, while 9 displayed cytotoxicity against two human osteosarcoma cell lines (U2OS and MG63) with IC50 values of 19.3 and 11.7 M, respectively.
部门归属[Bao, Jie; Zhai, Huijuan; Zhu, Kongkai; Yu, Jin-Hai; Zhang, Yuying; Wang, Yinyin; Jiang, Cheng-Shi; Zhang, Hua] Univ Jinan, Sch Biol Sci & Technol, 336 West Rd Nan Xinzhuang, Jinan 250022, Shandong, Peoples R China; [Zhang, Xiaoyong] South China Agr Univ, Coll Marine Sci, 483Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China; [Zhang, Yun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
学科领域Pharmacology & Pharmacy
关键词[WOS]Arthrinium ; pyridone alkaloid ; antibacterial activity ; cytotoxicity
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16951
专题中科院海洋生物资源可持续利用重点实验室
通讯作者bio_baoj@ujn.edu.cn; zhai18363005528@163.com; hkhhh.k@163.com; yujinhai12@sina.com; zhangyun@scsio.ac.cn; bio_wangyy@ujn.edu.cn; jiangchengshi-20@163.com; zhangxiaoyong@scau.edu.cn; bio_zhangh@ujn.edu.cn
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Bao, J,Zhai, HJ,Zhu, KK,et al. Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008[J]. MARINE DRUGS,2018,16(5):-174.
APA Bao, J.,Zhai, HJ.,Zhu, KK.,Yu, JH.,Zhang, YY.,...&bio_zhangh@ujn.edu.cn.(2018).Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008.MARINE DRUGS,16(5),-174.
MLA Bao, J,et al."Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp UJNMF0008".MARINE DRUGS 16.5(2018):-174.
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