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Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant
Zhang, HB; Tian, XX; Pu, XH; Zhang, QB; Zhang, WJ; Zhang, CS; czhang@scsio.ac.cn
2018
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume81Issue:5Pages:1219-1224
AbstractTiacumicin B (1, also known as fidaxomicin or difimicin) is a marketed drug for the treatment of Clostridium difficile infections. The biosynthetic pathway of 1 has been studied in Dactylosporangium aurantiacum subsp. hamdenensis NRRL 18085 and has enabled the identification of TiaM as a tailoring dihalogenase. Herein we report the isolation, structure elucidation, and bioactivity evaluation of 14 tiacumicin congeners (including 11 new ones) from the tiaM-inactivated mutant. A new tiacumicin congener, 3, with a propyl group at C-7 ''' of the aromatic ring was found to exhibit improved antibacterial activity.
Department[Zhang, Haibo; Zhang, Qugbo; Zhang, Wenjun; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Tian, Xiaoxing; Pu, Xiaohui] Henan Univ, Inst Mat Med, Pharmaceut Coll, Kaifeng 475004, Peoples R China
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16956
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorczhang@scsio.ac.cn
Recommended Citation
GB/T 7714
Zhang, HB,Tian, XX,Pu, XH,et al. Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(5):1219-1224.
APA Zhang, HB.,Tian, XX.,Pu, XH.,Zhang, QB.,Zhang, WJ.,...&czhang@scsio.ac.cn.(2018).Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant.JOURNAL OF NATURAL PRODUCTS,81(5),1219-1224.
MLA Zhang, HB,et al."Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant".JOURNAL OF NATURAL PRODUCTS 81.5(2018):1219-1224.
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