The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin
Deng, YC; Kang, DD; Shi, J; Zhou, WQ; Sun, AJ; Ju, JH; Zhu, XC; Shen, B; Duan, YW; Huang, Y; shenb@scripps.edu; ywduan66@yahoo.com; jonghuang@csu.edu.cn
2018
发表期刊MEDCHEMCOMM
卷号9期号:5页码:789-794
摘要A dozen oxime, hydrazine and hydrazide derivatives of platensimycin (PTM) analogues were synthesized, some of which showed strong antibacterial activities and were shown to be stable under the bioassay conditions. Docking analysis revealed that they have certain new interactions with beta-ketoacyl-[acyl carrier protein] synthase II (FabF), suggesting that Schiff base formation on its terpene scaffold is an effective strategy to diversify PTM structure.
部门归属[Deng, Youchao; Kang, Dingding; Shi, Jie; Zhou, Wenqing; Zhu, Xiangcheng; Shen, Ben; Duan, Yanwen; Huang, Yong] Cent S Univ, Xiangya Int Acad Translat Med, Changsha 410013, Hunan, Peoples R China; [Zhu, Xiangcheng; Duan, Yanwen] Hunan Engn Res Ctr Combinatorial Biosynth & Nat P, Changsha 410011, Hunan, Peoples R China; [Duan, Yanwen; Huang, Yong] Natl Engn Res Ctr Combinatorial Biosynth Drug Dis, Changsha 410011, Hunan, Peoples R China; [Sun, Aijun; Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 W Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Shen, Ben] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA; [Shen, Ben] Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; [Shen, Ben] Scripps Res Inst, Nat Prod Lib Initiat, Jupiter, FL 33458 USA
学科领域Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16958
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shenb@scripps.edu; ywduan66@yahoo.com; jonghuang@csu.edu.cn
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GB/T 7714
Deng, YC,Kang, DD,Shi, J,et al. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin[J]. MEDCHEMCOMM,2018,9(5):789-794.
APA Deng, YC.,Kang, DD.,Shi, J.,Zhou, WQ.,Sun, AJ.,...&jonghuang@csu.edu.cn.(2018).The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin.MEDCHEMCOMM,9(5),789-794.
MLA Deng, YC,et al."The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin".MEDCHEMCOMM 9.5(2018):789-794.
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