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Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89
Sun, JB; Shao, JL; Sun, CL; Song, YX; Li, QL; Lu, LC; Hu, YF; Gui, C; Zhang, H; Ju, JH; huazhang@gdmu.edu.cn; jju@scsio.ac.cn
2018
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY
Volume26Issue:8Pages:1488-1494
AbstractBorrelidin A (1) is produced by several species of Streptomyces and within its bioactive scaffold, the vinylic nitrile moiety is essential for activity. We report herein newly discovered members of the borrelidin family, borrelidin F (2), borrelidin G (3), borrelidin H (4) and borrelidin I (5); all were isolated from Streptomyces rochei SCSIO ZJ89 originating from a mangrove-derived sediment sample. These structurally diverse metabolites enabled a number of new structure-activity relationships (SARs) to be identified, especially with respect to the different configurations at the C11-OH and C12-C15 double bonds for which the absolute configurations were determined using spectroscopic methods. Importantly, borrelidin H (4) was found to have a therapeutic window superior to that of borrelidin A (1) in vitro and could inhibit migration of cancer cells. (C) 2018 Elsevier Ltd. All rights reserved.
Department[Sun, Jianbin; Sun, Changli; Song, Yongxiang; Li, Qinglian; Hu, Yunfeng; Gui, Chun; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Sun, Jianbin; Lu, Laichun] Chongqing Univ, Coll Bioengn, Chongqing 400044, Peoples R China; [Gui, Chun; Ju, Jianhua] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 110039, Peoples R China; [Shao, Junli; Zhang, Hua] Guangdong Med Univ, Dongguan Key Lab Environm Med, Inst Lab Med, Guangdong Prov Key Lab Med Mol Diagnost, 1 Xincheng Rd, Dongguan 523808, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS KeywordBorrelidin ; Streptomyces ; Cancer ; Cytotoxic activity ; Migration
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16961
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorhuazhang@gdmu.edu.cn; jju@scsio.ac.cn
Recommended Citation
GB/T 7714
Sun, JB,Shao, JL,Sun, CL,et al. Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2018,26(8):1488-1494.
APA Sun, JB.,Shao, JL.,Sun, CL.,Song, YX.,Li, QL.,...&jju@scsio.ac.cn.(2018).Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.BIOORGANIC & MEDICINAL CHEMISTRY,26(8),1488-1494.
MLA Sun, JB,et al."Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89".BIOORGANIC & MEDICINAL CHEMISTRY 26.8(2018):1488-1494.
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