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Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011
Luo, XW; Lin, XP; Tao, HM; Wang, JF; Li, JY; Yang, B; Zhou, XF; Liu, YH; xfzhou@scsio.ac.cn; yonghongliup@scsio.ac.cn
2018
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume81Issue:4Pages:934-941
AbstractSix new highly oxygenated chloroazaphilone derivatives, isochromophilones A-F (1-6), were obtained from the mangrove-derived fungus Diaporthe sp. SCSIO 41011, together with six known analogues (7-12). The structures of 1-6 including absolute configurations were determined by detailed NMR, MS spectroscopic analyses, and electronic circular dichroism spectra. Compounds 1 and 2 represent the first reported azaphilones lacking a carbonyl group at C-6. Compound 8 exhibited cytotoxic activities against three renal carcinoma cell lines, ACHN, OS-RC-2, and 786-O cells, with IC50 values ranging from 3.0 to 4.4 mu M, and 4 showed activity against 786-O cells with an ICso of 8.9 mu M. Further studies indicated that 4 induced apoptosis in 786-O cells in a dose- and time-dependent manner.
Department[Luo, Xiaowei; Lin, Xiuping; Wang, Junfeng; Li, Jiayi; Yang, Bin; Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [Luo, Xiaowei; Liu, Yonghong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Tao, Huaming; Li, Jiayi] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16971
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorxfzhou@scsio.ac.cn; yonghongliup@scsio.ac.cn
Recommended Citation
GB/T 7714
Luo, XW,Lin, XP,Tao, HM,et al. Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(4):934-941.
APA Luo, XW.,Lin, XP.,Tao, HM.,Wang, JF.,Li, JY.,...&yonghongliup@scsio.ac.cn.(2018).Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011.JOURNAL OF NATURAL PRODUCTS,81(4),934-941.
MLA Luo, XW,et al."Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011".JOURNAL OF NATURAL PRODUCTS 81.4(2018):934-941.
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