Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452
Zhong, WM; Wang, JF; Shi, XF; Wei, XY; Chen, YC; Zeng, Q; Xiang, Y; Chen, XY; Tian, XP; Xiao, ZH; Zhang, WM; Wang, FZ; Zhang, S; wmzhong@scsio.ac.cn; wangjunfeng@scsio.ac.cn; shixuefeng@scsio.ac.cn; wxy@scbg.ac.cn; chenyc@gdim.cn; 18489875310@163.com; xy920412@sina.cn; xychen1994@gmail.com; xinpengtian@scsio.ac.cn; xzh@scsio.ac.cn; wmzhang@gdim.cn; wangfazuo@scsio.ac.cn; zhsimd@scsio.ac.cn
2018
发表期刊MARINE DRUGS
卷号16期号:4页码:-136
摘要Three new prenylated indole 2,5-diketopiperazine alkaloids (1-3) with nine known ones (5-13), one new indole alkaloid (4), and one new bis-benzyl pyrimidine derivative (14) were isolated and characterized from the marine-derived fungus Eurotium sp. SCSIO F452. 1 and 2, occurring as a pair of diastereomers, both presented a hexahydropyrrolo[2,3-b] indole skeleton. Their chemical structures, including absolute configurations, were elucidated by 1D and 2D NMR, HRESIMS, quantum chemical calculations of electronic circular dichroism, and single crystal X-ray diffraction experiments. Most isolated compounds were screened for antioxidative potency. Compounds 3, 5, 6, 7, 9, 10, and 12 showed significant radical scavenging activities against DPPH with IC50 values of 13, 19, 4, 3, 24, 13, and 18 mu M, respectively. Five new compounds were evaluated for cytotoxic activities.
部门归属[Zhong, Wei-Mao; Wang, Jun-Feng; Shi, Xue-Feng; Zeng, Qi; Xiang, Yao; Chen, Xia-Yu; Tian, Xin-Peng; Xiao, Zhi-Hui; Wang, Fa-Zuo; Zhang, Si] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol,RNAM, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Zhong, Wei-Mao; Zeng, Qi; Xiang, Yao; Chen, Xia-Yu] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China; [Wei, Xiao-Yi] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China; [Chen, Yu-Chan; Zhang, Wei-Min] Guangdong Inst Microbiol, Guangdong Open Lab Appl Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, State Key Lab Appl Microbiol Southern China, 100 Cent Xianlie Rd, Guangzhou 510070, Guangdong, Peoples R China
学科领域Pharmacology & Pharmacy
关键词[WOS]prenylated indole alkaloid ; benzyl pyrimidine ; antioxidative and cytotoxic activities ; marine fungi
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/16972
专题中科院海洋生物资源可持续利用重点实验室
通讯作者wmzhong@scsio.ac.cn; wangjunfeng@scsio.ac.cn; shixuefeng@scsio.ac.cn; wxy@scbg.ac.cn; chenyc@gdim.cn; 18489875310@163.com; xy920412@sina.cn; xychen1994@gmail.com; xinpengtian@scsio.ac.cn; xzh@scsio.ac.cn; wmzhang@gdim.cn; wangfazuo@scsio.ac.cn; zhsimd@scsio.ac.cn
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Zhong, WM,Wang, JF,Shi, XF,et al. Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452[J]. MARINE DRUGS,2018,16(4):-136.
APA Zhong, WM.,Wang, JF.,Shi, XF.,Wei, XY.,Chen, YC.,...&zhsimd@scsio.ac.cn.(2018).Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452.MARINE DRUGS,16(4),-136.
MLA Zhong, WM,et al."Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452".MARINE DRUGS 16.4(2018):-136.
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