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Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats
Cai, BN; Wan, P; Sun, HL; Chen, DK; Chen, H; Chen, X; Pan, JY; jypan@scsio.ac.cn
2018
Source PublicationJOURNAL OF MEDICINAL FOOD
Volume21Issue:4Pages:348-355
AbstractChemotherapeutics, including 5-fluorouracil (5-FU), often damage the intestinal mucosal barrier and cause intestinal mucositis (IM). Supplementation with immunoregulatory polysaccharides from Crassostrea hongkongensis has been shown to positively influence the effectiveness and toxicity of 5-FU. Therefore, we studied the effects of oyster polysaccharides on 5-FU-induced intestinal mucosal damage in rats. The C30-60% ethanol-precipitated fraction of polysaccharides promoted IEC-6 cell proliferation and exhibited a maximal effect at a 0.0195 mg/mL concentration. Moreover, treatment with C30-60% polysaccharide-based nutrition formula (OPNF) partially prevented the 5-FU-induced degenerative changes in the histology and ultrastructure of small intestinal mucosa. In addition, the endotoxin level of rats fed with 5-FU and OPNF decreased to the normal control level. Furthermore, the 5-FU-induced increase of proinflammatory cytokine interleukin (IL)-2 and the decrease of anti-inflammatory cytokine IL-10 level in the peripheral blood were significantly attenuated by OPNF administration. In conclusion, Oyster C30-60% polysaccharides can ameliorate 5-FU-induced IM by partially preventing mucosal damage, reducing inflammation, and promoting immunity.
Department[Cai, Bingna; Wan, Peng; Sun, Huili; Chen, Deke; Chen, Hua; Pan, Jianyu] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Xin] Foshan Univ, Sch Environm & Chem Engn, Foshan, Peoples R China
Subject AreaPharmacology & Pharmacy ; Food Science & Technology ; Nutrition & Dietetics
WOS KeywordCrassostrea hongkongensis ; cytokine ; enteral nutrition ; intestinal mucosa ; polysaccharide
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16982
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorjypan@scsio.ac.cn
Recommended Citation
GB/T 7714
Cai, BN,Wan, P,Sun, HL,et al. Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats[J]. JOURNAL OF MEDICINAL FOOD,2018,21(4):348-355.
APA Cai, BN.,Wan, P.,Sun, HL.,Chen, DK.,Chen, H.,...&jypan@scsio.ac.cn.(2018).Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats.JOURNAL OF MEDICINAL FOOD,21(4),348-355.
MLA Cai, BN,et al."Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats".JOURNAL OF MEDICINAL FOOD 21.4(2018):348-355.
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