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New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001
Wang, JF; Zhou, LM; Chen, ST; Yang, B; Liao, SR; Kong, FD; Lin, XP; Wang, FZ; Zhou, XF; Liu, YH; wangjunfeng@scsio.ac.cn; yonghongliu@scsio.ac.cn
2018
Source PublicationFITOTERAPIA
Volume125Pages:49-54
AbstractSeven new compounds, including four new chlorinated diphenyl ethers, namely chrysines A-D (1-4), one new dichlorinated xanthone, chrysoxanthone (5), dichloroorcinol (6), and one new benzeneacetic acid derivative, 3-isopentyl-4-hydroxy phenylacetic acid methyl ester (7), along with fourteen known compounds (8-21), were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures were determined by extensive spectroscopic methods and X-ray single-crystal diffraction analysis. All of the isolated compounds (1 - 21) were evaluated for their a-glucosidase inhibitory activity using PNPG method. Among them, nine compounds (2, 3, 5, 6, 8, 9, 13, 17, and 18) exhibited inhibitory activity against alpha-glucosidase with IC50 values of 0.35, 0.20, 0.04, 0.16, 0.15, 0.09, 0.14, 0.14, and 0.12 mM, respectively (IC50 0.28 mM for the positive control acarbose).
Department[Wang, Jun-Feng; Chen, Sheng-Tian; Yang, Bin; Liao, Sheng-Rong; Lin, Xiu-Ping; Wang, Fa-Zuo; Zhou, Xue-Feng; Liu, Yong-Hong] Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China; [Zhou, Li-Man; Kong, Fan-Dong] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China; [Liu, Yong-Hong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Subject AreaPharmacology & Pharmacy
WOS KeywordPenicillium chrysogenum ; Diphenyl ether ; Xanthone ; alpha-Glucosidase inhibitory activity
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/16995
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorwangjunfeng@scsio.ac.cn; yonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
Wang, JF,Zhou, LM,Chen, ST,et al. New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001[J]. FITOTERAPIA,2018,125:49-54.
APA Wang, JF.,Zhou, LM.,Chen, ST.,Yang, B.,Liao, SR.,...&yonghongliu@scsio.ac.cn.(2018).New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001.FITOTERAPIA,125,49-54.
MLA Wang, JF,et al."New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001".FITOTERAPIA 125(2018):49-54.
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