SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Norisoprenoids from the Brown Alga Sargassum naozhouense Tseng et Lu
Peng, Y; Huang, RM; Lin, XP; Liu, YH; py00_2006@126.com; huangriming@scau.edu.cn; xiupinglin@hotmail.com; yonghongliu@scsio.ac.cn
2018
Source PublicationMOLECULES
Volume23Issue:2Pages:-348
AbstractA new C-11-norisoprenoid derivative, sargassumone (1), has been isolated from Sargassum naozhouense together with six known norisoprenoids and a highly oxygenated cyclopentene: (2R, 6S, 8S, 9S)-hexahydro-2,9-dihydroxy-4,4,8-trimethyl-6-acetyloxy-3(2H)-benzofuranone (2), (6S, 8S, 9R)-hexahydro-6,9-dihydroxy-4,4,8-trimethyl-2(2H)-benzofuranone (3), (6S, 8S, 9R)-hexahydro6,9- dihydroxy-4,4,8-trimethyl-2(2H)-benzofuranone (4), loliolide (5), (+)-epiloliolide (6), spheciospongones A (7), and (+)-kjellmanianone (8). compound 1 was identified on the basis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, and the absolute stereochemistry was defined by NOESY spectroscopy, minimizing energy calculation, and circular dichroism (CD) spectra. The known compounds 2-8, isolated from S. naozhouense for the first time, were identified by comparison of their physical and spectroscopic data with those reported in the literature. compound 6 was tested for its inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), antioxidant activity with 1,1-diphyl-2-picrylhydrazyl (DPPH) free radicals, and antimicrobial activity against resistant clinical isolates of Candida albicans, methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia coli.
Department[Peng, Yan] Lingnan Normal Univ, Life Sci & Technol Sch, Cunjin Rd 29, Zhanjiang 524048, Peoples R China; [Peng, Yan; Lin, Xiu-Ping; Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Key Lab Trop Marine Bioresources & Ecol,Guangdong, Xinggang West Rd 164, Guangzhou 510301, Guangdong, Peoples R China; [Huang, Ri-Ming] South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Food Qual & Safety, Wushan Rd 483, Guangzhou 510642, Guangdong, Peoples R China; [Liu, Yong-Hong] Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China; [Liu, Yong-Hong] South China Sea Bioresource Exploitat & Utilizat, Xinggang West Rd 164, Guangzhou 510301, Guangdong, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Chemistry
WOS Keywordbrown alga ; Sargassum naozhouense ; norisoprenoids ; cyclopentene
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17004
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorpy00_2006@126.com; huangriming@scau.edu.cn; xiupinglin@hotmail.com; yonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
Peng, Y,Huang, RM,Lin, XP,et al. Norisoprenoids from the Brown Alga Sargassum naozhouense Tseng et Lu[J]. MOLECULES,2018,23(2):-348.
APA Peng, Y.,Huang, RM.,Lin, XP.,Liu, YH.,py00_2006@126.com.,...&yonghongliu@scsio.ac.cn.(2018).Norisoprenoids from the Brown Alga Sargassum naozhouense Tseng et Lu.MOLECULES,23(2),-348.
MLA Peng, Y,et al."Norisoprenoids from the Brown Alga Sargassum naozhouense Tseng et Lu".MOLECULES 23.2(2018):-348.
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