Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules
Li, SH; Leung, PHM; Xu, XY; Wu, CH; polly.hm.leung@polyu.edu.hk
2018
发表期刊CHINESE CHEMICAL LETTERS
卷号29期号:2页码:313-316
摘要Bacterial quorum sensing (QS) molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules (autoinducers) and their corresponding receptors have been recognized as important therapeutic targets for drug -resistant infections and biofilm-associated infections (BAI). This study assessed the multiple biological effects of homogentisic acid gamma-lactone (HgAL), a furanone derivative. The anti -QS and anti-biofilm effects of HgAL against PAO1 strain were evaluated using CLSM, SEM, HPLC and other biochemical methods The results showed that HgAL could effectively inhibit the production of pyocyanin and extracellular matrix, as well as reduce the adherence ability and biofilm formation of Pseudomonas aeruginosa. Inhibition of virulence is attributed to the suppressive effect of HgAL on biosynthesis of 3-oxo-C-12-HSL and C-4-HSL (two kinds of QS signaling molecules in P. aeruginosa). Our results support HgAL as a potential agent for prevention of BAI in the healthcare settings. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
部门归属[Li, Shuihong; Leung, Polly H. M.] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong, Hong Kong, Peoples R China; [Li, Shuihong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China; [Xu, Xinya] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Wu, Chunhui] Univ Elect Sci & Technol China, Ctr Informat Biol, Chengdu 610054, Sichuan, Peoples R China
学科领域Chemistry
关键词[WOS]Homogentisic acid gamma-lactone ; Quorum sensing ; Biofilm ; Pseudomonas aeruginosa ; Pyocyanin
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/17009
专题中科院海洋生物资源可持续利用重点实验室
通讯作者polly.hm.leung@polyu.edu.hk
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GB/T 7714
Li, SH,Leung, PHM,Xu, XY,et al. Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules[J]. CHINESE CHEMICAL LETTERS,2018,29(2):313-316.
APA Li, SH,Leung, PHM,Xu, XY,Wu, CH,&polly.hm.leung@polyu.edu.hk.(2018).Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules.CHINESE CHEMICAL LETTERS,29(2),313-316.
MLA Li, SH,et al."Homogentisic acid gamma-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules".CHINESE CHEMICAL LETTERS 29.2(2018):313-316.
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