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Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32
Lai, ZZ; Yu, JC; Ling, HP; Song, YX; Yuan, J; Ju, JH; Tao, YW; Huang, HB; yywentao@aliyun.com; huanghb@scsio.ac.cn
2018
Source PublicationPLANTA MEDICA
Volume84Issue:3Pages:201-207
AbstractThree new angucycline glycosides, designated grincamycin I ( 1 ), J ( 2 ), and K ( 3 ), together with the known congener A-7884 ( 4 ), were isolated from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2 and 4 exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC (50) values ranging from 0.4 to 6.9 mu M. In addition, A-7884 ( 4 ) demonstrated antimicrobial activity against Micrococcus luteus with an MIC value of 1.95 mu g/mL.
Department[Lai, Zhenzhu; Ling, Huiping; Tao, Yiwen] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Guangdong, Peoples R China; [Lai, Zhenzhu; Ling, Huiping; Tao, Yiwen] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou, Guangdong, Peoples R China; [Lai, Zhenzhu; Song, Yongxiang; Ju, Jianhua; Huang, Hongbo] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou, Guangdong, Peoples R China; [Yu, Jianchen; Yuan, Jie] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou, Guangdong, Peoples R China
Subject AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS Keywordangucycline glycoside ; naphthacenequinone ; cytotoxicity ; marine actinomycete ; Streptomyces lusitanus ; Streptomycetaceae
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17011
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoryywentao@aliyun.com; huanghb@scsio.ac.cn
Recommended Citation
GB/T 7714
Lai, ZZ,Yu, JC,Ling, HP,et al. Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32[J]. PLANTA MEDICA,2018,84(3):201-207.
APA Lai, ZZ.,Yu, JC.,Ling, HP.,Song, YX.,Yuan, J.,...&huanghb@scsio.ac.cn.(2018).Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32.PLANTA MEDICA,84(3),201-207.
MLA Lai, ZZ,et al."Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32".PLANTA MEDICA 84.3(2018):201-207.
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