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Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations
Sun, CL; Zhang, CY; Qin, XJ; Wei, XY; Liu, Q; Li, QL; Ju, JH; jju@scsio.ac.cn
2018
Source PublicationTETRAHEDRON
Volume74Issue:1Pages:199-203
AbstractNaphthoquinone macrolides have attracted considerable synthetic interest due to their unique scaffolds, but there was no completion of total synthesis reported. In this study, genome mining and genetic manipulations were applied to stimulate the production of naphthoquinone macrolides from the deep-sea actinomycete Streptomyces olivaceus SCSIO T05; as a result, new metabolites olimycins A and B (1, 2) were isolated. The structures were elucidated on the basis of extensive spectroscopic data and X-ray single crystal diffraction studies. The results of these efforts enabled rectification of a key structural error made during previous efforts to characterize naphthoquinone macrolides. (C) 2017 Elsevier Ltd. All rights reserved.
Department[Sun, Changli; Zhang, Chunyan; Qin, Xiangjing; Liu, Qing; Li, Qinglian; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Wei, Xiaoyi] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Conservat & Sustainable Utilizat, Guangzhou 510650, Guangdong, Peoples R China; [Liu, Qing] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China; [Liu, Qing] Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China; [Ju, Jianhua] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 110039, Peoples R China
Subject AreaChemistry
WOS KeywordGenome mining ; Naphthoquinone macrolides ; Absolute configuration ; Structure rectification
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17018
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorjju@scsio.ac.cn
Recommended Citation
GB/T 7714
Sun, CL,Zhang, CY,Qin, XJ,et al. Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations[J]. TETRAHEDRON,2018,74(1):199-203.
APA Sun, CL.,Zhang, CY.,Qin, XJ.,Wei, XY.,Liu, Q.,...&jju@scsio.ac.cn.(2018).Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations.TETRAHEDRON,74(1),199-203.
MLA Sun, CL,et al."Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations".TETRAHEDRON 74.1(2018):199-203.
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