Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations
Sun, CL; Zhang, CY; Qin, XJ; Wei, XY; Liu, Q; Li, QL; Ju, JH; jju@scsio.ac.cn
2018
发表期刊TETRAHEDRON
卷号74期号:1页码:199-203
摘要Naphthoquinone macrolides have attracted considerable synthetic interest due to their unique scaffolds, but there was no completion of total synthesis reported. In this study, genome mining and genetic manipulations were applied to stimulate the production of naphthoquinone macrolides from the deep-sea actinomycete Streptomyces olivaceus SCSIO T05; as a result, new metabolites olimycins A and B (1, 2) were isolated. The structures were elucidated on the basis of extensive spectroscopic data and X-ray single crystal diffraction studies. The results of these efforts enabled rectification of a key structural error made during previous efforts to characterize naphthoquinone macrolides. (C) 2017 Elsevier Ltd. All rights reserved.
部门归属[Sun, Changli; Zhang, Chunyan; Qin, Xiangjing; Liu, Qing; Li, Qinglian; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China; [Wei, Xiaoyi] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Conservat & Sustainable Utilizat, Guangzhou 510650, Guangdong, Peoples R China; [Liu, Qing] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China; [Liu, Qing] Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China; [Ju, Jianhua] Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 110039, Peoples R China
学科领域Chemistry
关键词[WOS]Genome mining ; Naphthoquinone macrolides ; Absolute configuration ; Structure rectification
资助项目LMB
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/17018
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn
推荐引用方式
GB/T 7714
Sun, CL,Zhang, CY,Qin, XJ,et al. Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations[J]. TETRAHEDRON,2018,74(1):199-203.
APA Sun, CL.,Zhang, CY.,Qin, XJ.,Wei, XY.,Liu, Q.,...&jju@scsio.ac.cn.(2018).Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations.TETRAHEDRON,74(1),199-203.
MLA Sun, CL,et al."Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations".TETRAHEDRON 74.1(2018):199-203.
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