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Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus
Tan, YH; Yang, B; Lin, XP; Luo, XW; Pang, XY; Tang, L; Liu, YH; Li, XJ; Zhou, XF; lixiaoj@smu.edu.cn
2018
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume81Issue:1Pages:92-97
AbstractNitrobenzoyl sesquiterpenoids are rare from natural sources. Two new nitrobenzoyl sesquiterpenoids, insulicolide B (1) and insulicolide C (3), and the new natural product 14-O-acetylinsulicolide A (2) were isolated from culture extracts of the marine-derived fungus Aspergillus ochraceus JcmalF17, together with three known nitrobenzoyl sesquiterpenoids (4-6) and a derivative sesquiterpenoid (7). The structures of the new compounds, including their absolute configurations, were determined by NMR. and MS spectroscopic data analyses and comparison between the calculated and experimental ECD spectra. The nitrobenzoyl sesquiterpenoids (1-6) were evaluated for their cytotoxicities against three renal carcinoma cell lines, ACHN, OS-RC-2, and 786-O cells, and compounds 2, 4, and 5 displayed activities with IC50 values of 0.89 to 8.2 mu M. Further studies indicated that 2 arrested the cell cycle at the G0/G1 phase at a concentration of 1 mu M and induced late apoptosis at a concentration of 2 mu M after a 72 h treatment of 786-O cells.
Department[Tan, Yanhui; Yang, Bin; Lin, Xiuping; Luo, Xiaowei; Pang, Xiaoyan; Liu, Yonghong; Zhou, Xuefeng] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Tan, Yanhui; Tang, Lan; Li, Xiaojuan] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Funding ProjectLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17033
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorlixiaoj@smu.edu.cn
Recommended Citation
GB/T 7714
Tan, YH,Yang, B,Lin, XP,et al. Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(1):92-97.
APA Tan, YH.,Yang, B.,Lin, XP.,Luo, XW.,Pang, XY.,...&lixiaoj@smu.edu.cn.(2018).Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus.JOURNAL OF NATURAL PRODUCTS,81(1),92-97.
MLA Tan, YH,et al."Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus".JOURNAL OF NATURAL PRODUCTS 81.1(2018):92-97.
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