SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries
Zhang, Chunyan1; Yang, Zhijie1; Qin, Xiangjing; Ma, Junying; Sun, Changli; Huang, Hongbo; Li, Qinglian; Ju, Jianhua1
2018
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume20Issue:23Pages:7633
AbstractA silent dibenzoxazepinone (DBP) biosynthetic gene cluster (myc) was mutagenically activated in Streptomyces olivaceus SCSIO T05, enabling the discovery of mycemycin C (4) and three new analogues [mycemycins F-H (1-3)]. Gene disruption, complementation experiments, and enzymatic assays unveiled salicylic acid and 5-Cl-kynurenine as biosynthetic precursors and shed significant functional insights into MycO, MycB, MycR, and MycJ, enzymes responsible for fine-tuning of the DBP scaffold.
DepartmentLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17594
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Chunyan,Yang, Zhijie,Qin, Xiangjing,et al. Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries[J]. ORGANIC LETTERS,2018,20(23):7633, 7636.
APA Zhang, Chunyan.,Yang, Zhijie.,Qin, Xiangjing.,Ma, Junying.,Sun, Changli.,...&Ju, Jianhua.(2018).Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries.ORGANIC LETTERS,20(23),7633.
MLA Zhang, Chunyan,et al."Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries".ORGANIC LETTERS 20.23(2018):7633.
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