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Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death
Zheng, Qi1,2; Ji, Huasong4; Wei, Shina3; Tang, Jufen1,2; Lu, Yishan1,2; Cai, Jia1,2; Jian, Jichang1,2; Qin, Qiwei3
2018
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume83Pages:436
AbstractBcl-2 family proteins play essential roles in modulating immune response and controlling cells' fate. Bcl-xL is one of anti-apoptotic protein in this family. In this study, a new Bcl-xL homolog (EcBcl-xL) was identified and characterized from orange-spotted grouper, Epinephelus coioides. EcBcl-xL encoded a 221 amino acid peptides that shared 86% identity to Larimichthys crocea Bcl-xL protein, contained four conserved BH domains and one transmembrane region. The predicted three-dimensional structure of EcBcl-xL was similar with Homo sapiens BclxL. EcBcl-xL widely expressed in all tested tissues with highest expression in head kidney. Its expression level was significantly up-regulated after SGIV infection in vivo. Furthermore, overexpression of EcBcl-xL could inhibit SGIV-induced nonapoptotic cell death and suppressed viral genes transcriptions in GS cells. Our findings suggested that EcBcl-xL might play a role during virus infection through modulating SGIV-induced nonapoptotic cell death.
DepartmentLMB
KeywordEpinephelus coioides Bcl-xL Singapore grouper iridovirus (SGIV) Viral gene Nonapoptotic cell death
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17600
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524088, Peoples R China
2.Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China
3.Guangdong Key Lab Control Dis Aquat Econ Anim, Zhanjiang 524088, Peoples R China
4.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
5.Zhaoqing Dahuanong Biol Med Co Ltd, Zhaoqing, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Qi,Ji, Huasong,Wei, Shina,et al. Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death[J]. FISH & SHELLFISH IMMUNOLOGY,2018,83:436, 442.
APA Zheng, Qi.,Ji, Huasong.,Wei, Shina.,Tang, Jufen.,Lu, Yishan.,...&Qin, Qiwei.(2018).Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death.FISH & SHELLFISH IMMUNOLOGY,83,436.
MLA Zheng, Qi,et al."Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death".FISH & SHELLFISH IMMUNOLOGY 83(2018):436.
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