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Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49
Chen, Yaping; Chen, Ruyan1; Xu, Jinhuai1; Tian, Yongqi1; Xu, Jiangping; Liu, Yonghong2
2018
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:11Pages:2844
AbstractTwo novel altenusin-thiazole hybrids named altenusinoides A and B (1 and 2), a new benzothiazole derivative (3), and three known altenusin derivatives (4-6) have been obtained from the solid culture of the marine sponge-derived fungal strain, Alternaria sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds 1 and 2 possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound 3 represents the first benzothiazole derivative from fungi. Compounds 4 and 5 showed significant DPPH free-radical-scavenging activities with the prominent IC50 values of 10.7 +/- 0.09 M and 100.6 +/- 0.025 mu M, respectively. Additionally, compound 5 exhibited COX-2 inhibitory activity with an IC50 value of 9.5 +/- 0.08 mu M.
DepartmentLMB
Keywordsponge-derived fungus Alternaria sp SCSIOS02F49 altenusin/thiazole hybrids benzothiazole derivative
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17611
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
2.Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350116, Fujian, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Chen, Yaping,Chen, Ruyan,Xu, Jinhuai,et al. Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49[J]. MOLECULES,2018,23(11):2844.
APA Chen, Yaping,Chen, Ruyan,Xu, Jinhuai,Tian, Yongqi,Xu, Jiangping,&Liu, Yonghong.(2018).Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49.MOLECULES,23(11),2844.
MLA Chen, Yaping,et al."Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49".MOLECULES 23.11(2018):2844.
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