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Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008
Liang, Xiao; Huang, Zhong-Hui; Ma, Xuan; Qi, Shu-Hua
2018
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:11Pages:448
AbstractSeven new unstable tetramic acid derivatives, cladosporiumins I-O (1-7), together with the known analogue cladodionen (8) were isolated from the extract of the deep-sea-derived fungus Cladosporium sphaerospermum EIODSF 008. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations and ECD spectra. Compound 4 was a Mg complex of tetramic acid derivative. In acidic solvent, 4 could change to 1 and 6, and 7 could change to 5. In addition, 1, 5 and 8 existed as two exchangeable isomers, respectively. The structures of cladosporiumins E-H were reassigned as their Na complexes. The antibacterial and cytotoxic activities of 1-8 were also evaluated. However, because of their instability, all of the isolated compounds did not show significant antibacterial activity as the preliminary EtOAc extracts of the fungal strain.
DepartmentLMB
Keyworddeep-sea-derived fungus Cladosporium sphaerospermum tetramic acid cladosporiumins I-O
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17612
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.[Liang, Xiao
2.Huang, Zhong-Hui
3.Ma, Xuan
4.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
5.[Liang, Xiao
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liang, Xiao,Huang, Zhong-Hui,Ma, Xuan,et al. Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008[J]. MARINE DRUGS,2018,16(11):448.
APA Liang, Xiao,Huang, Zhong-Hui,Ma, Xuan,&Qi, Shu-Hua.(2018).Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008.MARINE DRUGS,16(11),448.
MLA Liang, Xiao,et al."Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008".MARINE DRUGS 16.11(2018):448.
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