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Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46
Tian, Yongqi1; Lin, Xiuping1; Zhou, Xuefeng1; Liu, Yonghong1,2
AbstractSeven new phenol derivatives named coleophomones E and F (1, 2), diorcinols L and M (3, 4), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (5), porric acid E (6), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (7), were isolated from the EtOAc extract of the marine sponge-derived fungus Didymellaceae sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of 1 and 2 contains an unusual spiro [cyclohexane-1,2'-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound 3 displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC50 values 5.7-9.6 mu M) and weak activities against other five cell lines, while 8 showed weak cytotoxicities against HeLa and HL7702 cells. Compound 6 displayed COX-2 inhibitory activity with IC50 value of 3.3 mu M.
Keywordsponge-derived fungus Didymellaceae sp. Phenol derivatives cytotoxic COX-2 inhibitory
Document Type期刊论文
Affiliation1.Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou, Fujian, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Tian, Yongqi,Lin, Xiuping,Zhou, Xuefeng,et al. Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46[J]. FRONTIERS IN CHEMISTRY,2018,6:536.
APA Tian, Yongqi,Lin, Xiuping,Zhou, Xuefeng,&Liu, Yonghong.(2018).Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46.FRONTIERS IN CHEMISTRY,6,536.
MLA Tian, Yongqi,et al."Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46".FRONTIERS IN CHEMISTRY 6(2018):536.
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