Knowledge Management System Of South China Sea Institute of Oceanology,CAS
| Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46 | |
| Tian, Yongqi1; Lin, Xiuping1; Zhou, Xuefeng1; Liu, Yonghong1,2 | |
| 2018 | |
| Source Publication | FRONTIERS IN CHEMISTRY
 |
| ISSN | 2296-2646 |
| Volume | 6Pages:536 |
| Abstract | Seven new phenol derivatives named coleophomones E and F (1, 2), diorcinols L and M (3, 4), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (5), porric acid E (6), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (7), were isolated from the EtOAc extract of the marine sponge-derived fungus Didymellaceae sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of 1 and 2 contains an unusual spiro [cyclohexane-1,2'-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound 3 displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC50 values 5.7-9.6 mu M) and weak activities against other five cell lines, while 8 showed weak cytotoxicities against HeLa and HL7702 cells. Compound 6 displayed COX-2 inhibitory activity with IC50 value of 3.3 mu M. |
| Department | LMB |
| Keyword | sponge-derived fungus Didymellaceae sp. Phenol derivatives cytotoxic COX-2 inhibitory |
| Document Type | 期刊论文 |
| Identifier | http://ir.scsio.ac.cn/handle/344004/17614 |
| Collection | 中科院海洋生物资源可持续利用重点实验室 |
| Affiliation | 1.Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou, Fujian, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Tian, Yongqi,Lin, Xiuping,Zhou, Xuefeng,et al. Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46[J]. FRONTIERS IN CHEMISTRY,2018,6:536. |
| APA | Tian, Yongqi,Lin, Xiuping,Zhou, Xuefeng,&Liu, Yonghong.(2018).Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46.FRONTIERS IN CHEMISTRY,6,536. |
| MLA | Tian, Yongqi,et al."Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp SCSIO F46".FRONTIERS IN CHEMISTRY 6(2018):536. |
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| File Name/Size | DocType | Version | Access | License | ||
| Phenol Derivatives F（1258KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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