SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization
Huang, Chunshuai1; Yang, Chunfang; Zhu, Yiguang; Zhang, Wenjun; Yuan, Chengshan; Zhang, Changsheng1
2018
Source PublicationFRONTIERS IN CHEMISTRY
ISSN2296-2646
Volume6Pages:528
AbstractThe structure diversity of type II polyketide synthases-derived bacterial aromatic polyketides is often enhanced by enzyme controlled or spontaneous cyclizations. Here we report the discovery of bacterial aromatic polyketides generated from 5 different cyclization modes and pathway crosstalk between the host and the heterologous fluostatin biosynthetic gene cluster derived from a marine bacterium. The discovery of new compound SEK43F (2) represents an unusual carbon skeleton resulting from a pathway crosstalk, in which a pyrrole-like moiety derived from the host Streptomyces albus J1074 is fused to an aromatic polyketide SEK43 generated from the heterologous fluostatin type II PKSs. The occurrence of a new congener, fluoquinone (3), highlights a bacterial aromatic polyketide that is exceptionally derived from a characteristic fungal F-mode first-ring cyclization. This study expands our knowledge on the power of bacterial type II PKSs in diversifying aromatic polyketides.
DepartmentLMB
Keywordheterologous expression aromatic polyketides type II polyketide synthase cyclization modes pathway crosstalk
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17620
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, RNAM Ctr Marine Microbiobgy, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Huang, Chunshuai,Yang, Chunfang,Zhu, Yiguang,et al. Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization[J]. FRONTIERS IN CHEMISTRY,2018,6:528.
APA Huang, Chunshuai,Yang, Chunfang,Zhu, Yiguang,Zhang, Wenjun,Yuan, Chengshan,&Zhang, Changsheng.(2018).Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization.FRONTIERS IN CHEMISTRY,6,528.
MLA Huang, Chunshuai,et al."Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization".FRONTIERS IN CHEMISTRY 6(2018):528.
Files in This Item:
File Name/Size DocType Version Access License
Marine Bacterial Aro(1289KB)期刊论文出版稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.