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Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis
Li, Songwei1; Ye, Fei; Zhu, Zhengdan; Huang, Hui2; Mao, Shuichun1; Guo, Yuewei
2018
Source PublicationACTA PHARMACEUTICA SINICA B
ISSN2211-3835
Volume8Issue:6Pages:944
AbstractEight cembrane-type diterpenoids, namely, (+)-(6R)-6-hydroxyisosarcophytoxide (1), (+)-(6R)-6-acetoxyisosarcophytoxide (2), (+)-17-hydroxyisosarcophytoxide (3), sarcomililatins A-D (4-7), and sarcomililatol (8), were isolated from the soft coral Sarcophyton mililatensis collected from Weizhou Island, Guangxi Autonomous Region, together with 2 known related analogues, (+)-isosarco phytoxide (9) and (+)-isosarcophine (10). The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. The absolute configuration of compound 1 was established by the modified Mosher's method, while the absolute configurations of compounds 4 and 5 were assigned by electronic circular dichroism (ECD) spectroscopy and that of compound 8 was established by time-dependent density functional theory electronic circular dichroism (TD-DFT ECD) calculation. In in vitro bioassays, compound 9 displayed significant cytotoxicity against the human cancer cell lines human promyelocytic leukemia cells (HL-60) and human lung adenocarcinoma cells (A-549) with IC50 values of 0.78 +/- 0.21 and 1.26+0.80 +/- 1.26+0.80 mu mol/L, respectively. Compounds 4 and 9 also showed moderate inhibitory effects on the TNF alpha-induced Nuclear factor kappa B (NF-kappa B, a therapeutical target in cancer) activation, showing IC50 values of 35.23 +/- 12.42 and 22.52 +/- 4.44 mu mol/L, respectively. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
DepartmentLMB
KeywordSoft coral Sureophyton Sarcophyton mililatensis Cembrane-type diterpenoids Modified Mosher's method ECD calculation Cytotoxieity NE-kappa B inhibitory activity
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17625
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Li, Songwei,Ye, Fei,Zhu, Zhengdan,et al. Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis[J]. ACTA PHARMACEUTICA SINICA B,2018,8(6):944, 955.
APA Li, Songwei,Ye, Fei,Zhu, Zhengdan,Huang, Hui,Mao, Shuichun,&Guo, Yuewei.(2018).Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis.ACTA PHARMACEUTICA SINICA B,8(6),944.
MLA Li, Songwei,et al."Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis".ACTA PHARMACEUTICA SINICA B 8.6(2018):944.
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