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Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster
Huang, Xian-De; Dai, Jia-ge; Lin, Ke-tao; Liu, Mei; Ruan, Hui-ting; Zhang, Hua; Liu, Wen-guang; He, Mao-Xian; Zhao, Mi9
AbstractLong noncoding RNAs (lncRNAs), once thought to be nonfunctional, have recently been shown to participate in the multilevel regulation of transcriptional, posttranscriptional and epigenetic modifications and to play important roles in various biological processes, including immune responses. However, the expression and roles of lncRNAs in invertebrates, especially nonmodel organisms, remain poorly understood. In this study, by comparing a transcriptome to the PfIRF-2 genomic structure, we identified lncIRF-2 in the PfIRF-2 genomic intron. The results of the RNA interference (RNAi) and the nucleus grafting experiments indicated that PfIRF-2 might have a negative regulatory effect on lncIRF-2, and PfIRF-2 and lncIRF-2 may have a positive regulatory effect on PfIL-17. Additionally, lncIRF-2, PfIRF-2 and PfIL-17 were involved in responses to the nucleus graft. These results will enhance the knowledge of lncIRF-2, IRF-2, and IL-17 functions in both pearl oysters and other invertebrates.
KeywordPearl oyster lncIRF-2 PfIL-17 RNA interference Nucleus grafting
Document Type期刊论文
Affiliation1.[Huang, Xian-De
2.Dai, Jia-ge
3.Lin, Ke-tao
4.Liu, Mei
5.South China Agr Univ, Coll Marine Sci, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China
6.[Huang, Xian-De
7.Zhang, Hua
8.Liu, Wen-guang
9.He, Mao-Xian
10.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, South China Sea Inst Oceanol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Huang, Xian-De,Dai, Jia-ge,Lin, Ke-tao,et al. Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2018,81:108, 112.
APA Huang, Xian-De.,Dai, Jia-ge.,Lin, Ke-tao.,Liu, Mei.,Ruan, Hui-ting.,...&Zhao, Mi.(2018).Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster.FISH & SHELLFISH IMMUNOLOGY,81,108.
MLA Huang, Xian-De,et al."Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster".FISH & SHELLFISH IMMUNOLOGY 81(2018):108.
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