Knowledge Management System Of South China Sea Institute of Oceanology,CAS
| Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster | |
| Huang, Xian-De; Dai, Jia-ge; Lin, Ke-tao; Liu, Mei; Ruan, Hui-ting; Zhang, Hua; Liu, Wen-guang; He, Mao-Xian; Zhao, Mi9 | |
| 2018 | |
| Source Publication | FISH & SHELLFISH IMMUNOLOGY
 |
| ISSN | 1050-4648 |
| Volume | 81Pages:108 |
| Abstract | Long noncoding RNAs (lncRNAs), once thought to be nonfunctional, have recently been shown to participate in the multilevel regulation of transcriptional, posttranscriptional and epigenetic modifications and to play important roles in various biological processes, including immune responses. However, the expression and roles of lncRNAs in invertebrates, especially nonmodel organisms, remain poorly understood. In this study, by comparing a transcriptome to the PfIRF-2 genomic structure, we identified lncIRF-2 in the PfIRF-2 genomic intron. The results of the RNA interference (RNAi) and the nucleus grafting experiments indicated that PfIRF-2 might have a negative regulatory effect on lncIRF-2, and PfIRF-2 and lncIRF-2 may have a positive regulatory effect on PfIL-17. Additionally, lncIRF-2, PfIRF-2 and PfIL-17 were involved in responses to the nucleus graft. These results will enhance the knowledge of lncIRF-2, IRF-2, and IL-17 functions in both pearl oysters and other invertebrates. |
| Department | LMB |
| Keyword | Pearl oyster lncIRF-2 PfIL-17 RNA interference Nucleus grafting |
| Document Type | 期刊论文 |
| Identifier | http://ir.scsio.ac.cn/handle/344004/17630 |
| Collection | 中科院海洋生物资源可持续利用重点实验室 |
| Affiliation | 1.[Huang, Xian-De 2.Dai, Jia-ge 3.Lin, Ke-tao 4.Liu, Mei 5.South China Agr Univ, Coll Marine Sci, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China 6.[Huang, Xian-De 7.Zhang, Hua 8.Liu, Wen-guang 9.He, Mao-Xian 10.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, South China Sea Inst Oceanol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Huang, Xian-De,Dai, Jia-ge,Lin, Ke-tao,et al. Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2018,81:108, 112. |
| APA | Huang, Xian-De.,Dai, Jia-ge.,Lin, Ke-tao.,Liu, Mei.,Ruan, Hui-ting.,...&Zhao, Mi.(2018).Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster.FISH & SHELLFISH IMMUNOLOGY,81,108. |
| MLA | Huang, Xian-De,et al."Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster".FISH & SHELLFISH IMMUNOLOGY 81(2018):108. |
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| Regulation of IL-17 （1871KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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