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Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209
Dai, Yu1; Lin, Yun2,3; Pang, Xiaoyan1; Luo, Xiaowei1; Salendra, Limbadri1; Wang, Junfeng; Zhou, Xuefeng; Lu, Yongjun2,3; Yang, Bin; Liu, Yonghong
2018
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume154Pages:56
AbstractFive new peptides, Sinulariapeptides A - E together with seven known peptides (6-12) were isolated from the soft coral associated fungus Simplicillium sp. SCSIO 41209. The structures of the new compounds and their absolute configurations were established on the basis of spectroscopic analysis including NMR, MS and ECD. All the Compounds (except sinulariapeptides B - D) were tested for the inhibitory activities of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), and antifungal activities against five plant pathogenic fungi. Simplicilliumtides B and cyclo(L-Val-L-Pro) showed inhibitory activity with the IC50 values of 35.0 and 25.9 mu M, sinulariapeptides A, simplicilliumtides J, verlamelins A and B exhibited potent inhibition against Colletotrichum asianum with the MIC values of range from 4.9 to 9.8 mu g/mL and simplicilliumtides J, verlamelins A and B displayed inhibition against Pyricularia oryza Cav with the MIC values in the range of 19.5-78.1 mu g/ml, respectively.
DepartmentLMB
KeywordSimplicillium sp SCSIO41209 Soft coral Peptides Sinulariapeptides Antifungal
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17633
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Biomed Ctr, Guangzhou 510275, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Dai, Yu,Lin, Yun,Pang, Xiaoyan,et al. Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209[J]. PHYTOCHEMISTRY,2018,154:56, 62.
APA Dai, Yu.,Lin, Yun.,Pang, Xiaoyan.,Luo, Xiaowei.,Salendra, Limbadri.,...&Liu, Yonghong.(2018).Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209.PHYTOCHEMISTRY,154,56.
MLA Dai, Yu,et al."Peptides from the Soft Coral-associated Fungus Simplicillium sp SCSIO41209".PHYTOCHEMISTRY 154(2018):56.
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