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Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012
Limbadri, Salendra1; Luo, Xiaowei1; Lin, Xiuping; Liao, Shengrong; Wang, Junfeng; Zhou, Xuefeng; Yang, Bin; Liu, Yonghong
2018
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:9Pages:2379
AbstractTwo new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P-1 (6) along with five known compounds (3-5, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 mu g/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 mu g/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 mu g/mL.
DepartmentLMB
Keyworddeep sea-derived fungus Aspergillus fumigatus SCSIO 41012 indole alkaloids steroids antibacterial activity antifungal activity
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17637
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,Res Ctr Marine M, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Limbadri, Salendra,Luo, Xiaowei,Lin, Xiuping,et al. Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012[J]. MOLECULES,2018,23(9):2379.
APA Limbadri, Salendra.,Luo, Xiaowei.,Lin, Xiuping.,Liao, Shengrong.,Wang, Junfeng.,...&Liu, Yonghong.(2018).Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012.MOLECULES,23(9),2379.
MLA Limbadri, Salendra,et al."Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012".MOLECULES 23.9(2018):2379.
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