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alpha-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3
Wu, Yingnan; Chen, Yan1; Huang, Xishan; Pan, Yahong; Liu, Zhaoming2; Yan, Tao3; Cao, Wenhao3; She, Zhigang1
2018
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:9Pages:307
AbstractTwo new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3-6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1-6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their -glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5-4.5 M.
DepartmentLMB
Keywordalpha-glucosidase inhibitors mangrove endophytic fungus Aspergillus flavus
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17638
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Sch Marine Sci, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China
3.Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangzhou 510075, Guangdong, Peoples R China
4.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wu, Yingnan,Chen, Yan,Huang, Xishan,et al. alpha-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3[J]. MARINE DRUGS,2018,16(9):307.
APA Wu, Yingnan.,Chen, Yan.,Huang, Xishan.,Pan, Yahong.,Liu, Zhaoming.,...&She, Zhigang.(2018).alpha-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3.MARINE DRUGS,16(9),307.
MLA Wu, Yingnan,et al."alpha-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3".MARINE DRUGS 16.9(2018):307.
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