SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis
Li, Qinglian; Ding, Wenjuan1; Yao, Ziwei1; Tu, Jiajia; Wang, Liyan2; Huang, Hongbo; Li, Shengying3; Ju, Jianhua1
2018
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume20Issue:16Pages:4854
AbstractMembers of the abyssomicin class of natural products are characterized by a novel vinylic bridged ether ring. In this study, in vivo gene inactivation, structure elucidation of the accumulated intermediate abyssomicin 6, and in vitro enzyme assays enabled the identification of a cytochrome P450 enzyme, AbmV. AbmV carries out domino reactions involving bridged ether installation and C-11 hydroxylation during the biosynthesis of neoabyssomicins/abyssomicins in S. koyangensis SCSIO 5802.
DepartmentLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17645
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Shenzhen Univ, Coll Bio & Marine Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China
4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, CAS Key Lab Biofuels, Qingdao 266000, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Li, Qinglian,Ding, Wenjuan,Yao, Ziwei,et al. AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis[J]. ORGANIC LETTERS,2018,20(16):4854, 4857.
APA Li, Qinglian.,Ding, Wenjuan.,Yao, Ziwei.,Tu, Jiajia.,Wang, Liyan.,...&Ju, Jianhua.(2018).AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.ORGANIC LETTERS,20(16),4854.
MLA Li, Qinglian,et al."AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis".ORGANIC LETTERS 20.16(2018):4854.
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