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Spiro-Phthalides and Isocoumarins Isolated from the Marine-Sponge-Derived Fungus Setosphaeria sp SCSIO41009
Pang, Xiaoyan1; Lin, Xiuping; Yang, Jie2; Zhou, Xuefeng; Yang, Bin; Wang, Junfeng; Liu, Yonghong1
2018
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:8Pages:1860
AbstractFourteen new polyketides classified as four phthalides, setosphalides A and B, 5-O-desmethyl- colletotrialide, and (S)-colletotrialide (1-4), three isocoumar-in derivatives, exserolides I-K (5-7), four pyrones, setosphapyrones A-D (8-11), one furanone (12), and two depsidones (13 and 14), along with 17 known polyketides were isolated from cultures of the sponge-derived fungus Setosphaeria sp. SCSIO41009. The structures and absolute Setosphaeria sp. SCSIO41009 configurations of these new compounds (1-14) were determined by spectroscopic analyses, X-ray diffraction, chiral-phase HPLC analysis, modified Mosher's method, and comparison of ECD spectra to calculations. Setosphalides A (1) and B (2) are the first examples possessing a 5,5 spiroketal skeleton in phthalide derivatives. Botryorhodines I (13) and J (14) showed moderate antifungal activities against the phytopathogenic fungi Colletotrichum asianum and Colletotrichum acutatum. Compound 18 (7-O-demethylmonocerin) exhibited potent radical scavenging activity against DPPH.
DepartmentLMB
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17650
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510220, Guangdong, Peoples R China
2.Univers Chinese Acad Sci, Beijing 100049, Peoples R China
3.Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Pang, Xiaoyan,Lin, Xiuping,Yang, Jie,et al. Spiro-Phthalides and Isocoumarins Isolated from the Marine-Sponge-Derived Fungus Setosphaeria sp SCSIO41009[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(8):1860, 1868.
APA Pang, Xiaoyan.,Lin, Xiuping.,Yang, Jie.,Zhou, Xuefeng.,Yang, Bin.,...&Liu, Yonghong.(2018).Spiro-Phthalides and Isocoumarins Isolated from the Marine-Sponge-Derived Fungus Setosphaeria sp SCSIO41009.JOURNAL OF NATURAL PRODUCTS,81(8),1860.
MLA Pang, Xiaoyan,et al."Spiro-Phthalides and Isocoumarins Isolated from the Marine-Sponge-Derived Fungus Setosphaeria sp SCSIO41009".JOURNAL OF NATURAL PRODUCTS 81.8(2018):1860.
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