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Natural products for treating colorectal cancer: A mechanistic review
Huang, Xuan-mei; Yang, Zhi-jie; Xie, Qing; Zhang, Zi-kang; Zhang, Hua3; Ma, Jun-ying
Volume117Pages:UNSP 109142
AbstractColorectal cancer (CRC) is one of the most common types of cancers in humans and is closely linked to the global cancer-related mortalities worldwide. Molecular pathological epidemiology studies can reveal the risk factors of CRC and contribute to biomarker research and precision medicine. The current clinical treatment for CRC mainly involves surgery and chemotherapy. However, because of the occurrence of side effects and the emergence of drug resistance, there is an urgent need to find new and more effective drugs for CRC treatment. An increasing number of studies have demonstrated that many natural products possess effective anti-CRC effects and may serve as alternative chemotherapy agents for CRC treatment. In this review, we summarize the natural products with anti-CRC effects from different sources based on the chemical structures such as alkaloids, polysaccharides, polyphenols, terpenoid, unsaturated fatty acids, and discuss the natural product-derived drugs used clinically for colorectal cancer treatment. Furthermore, natural products of marine origin are also discussed for their enormous potential to serve as the candidate drugs. Notably, we generalize the experiment-based molecular mechanisms and the regulatory networks whereby natural products exert anticancer effects on cell proliferation, metastasis, apoptosis, autophagy, and angiogenesis.
KeywordNatural products Colorectal cancer Anti-cancer effects Molecular mechanisms Regulation networks
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Document Type期刊论文
Affiliation1.[Huang, Xuan-mei
2.Xie, Qing
3.Zhang, Zi-kang
4.Guangdong Med Univ, Marine Biomed Res Inst, Inst Lab Med, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan 523808, Peoples R China
5.[Yang, Zhi-jie
6.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Huang, Xuan-mei,Yang, Zhi-jie,Xie, Qing,et al. Natural products for treating colorectal cancer: A mechanistic review[J]. BIOMEDICINE & PHARMACOTHERAPY,2019,117:UNSP 109142.
APA Huang, Xuan-mei,Yang, Zhi-jie,Xie, Qing,Zhang, Zi-kang,Zhang, Hua,&Ma, Jun-ying.(2019).Natural products for treating colorectal cancer: A mechanistic review.BIOMEDICINE & PHARMACOTHERAPY,117,UNSP 109142.
MLA Huang, Xuan-mei,et al."Natural products for treating colorectal cancer: A mechanistic review".BIOMEDICINE & PHARMACOTHERAPY 117(2019):UNSP 109142.
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