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Molecular identification of GnIH and its potential role in reproductive physiology and male pregnancy of the lined seahorse (Hippocampus erectus)
Zhang, Huixian; Chen, Lingzhen1; Zhang, Bo1; Lin, Qiang1
2019
Source PublicationGENERAL AND COMPARATIVE ENDOCRINOLOGY
ISSN0016-6480
Volume279Pages:196
AbstractThe gonadotropin-inhibitory hormone (GnIH) plays a negative role in the hypothalamic-pituitary-gonadal (HPG) axis by inhibiting gonadotropin secretion in vertebrates. Male pregnancy and ovoviviparous behavior are unique phenomena among vertebrates. To better understand the neuroendocrine regulatory mechanisms in ovoviviparous fish with male pregnancy, we identified the orthologous GnIH gene in the lined seahorse (Hippocampus erectus). The full-length cDNA of the GnIH precursor was 658 base pairs with an open reading frame of 528 base pairs that encoded a 175-amino acid prepro-GnIH peptide. The seahorse GnIH precursor contained two putative LPXRFamide peptides. Both seahorse LPXRFa-1 and LPXRFa-2 were found to be unique among vertebrates. The synteny blocks of GnIH gene loci were conserved in mammals and teleosts. Tissue distribution analysis revealed that seahorse GnIH mRNA was mainly expressed in the hypothalamus, with relatively high levels observed in the brood pouch. The expression patterns of seahorse GnIH during different reproductive stages and pregnancy stages were also detected, and GnIH mRNA expression was significantly reduced during the early puberty stage. In addition, GnIH mRNA expression was significantly increased during the pregnancy stage compared to non-pregnancy stages. In summary, our results reveal the existence of GnIH in ovoviviparous fish and suggest its involvement in regulation of reproductive behavior and male pregnancy in the male seahorse.
DepartmentLMB
KeywordGonadotropin-inhibitory hormone LPXRF Pregnancy Seahorse Teleost
DOI10.1016/j.ygcen.2019.04.018
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Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/17805
Collection中科院海洋生物资源可持续利用重点实验室
Affiliation1.Chinese Acad Sci, Inst South China Sea Ecol & Environm Engn, Guangdong Prov Key Lab Appl Marine Biol Lamb, South China Sea Inst Oceanol,CAS Key Lab Trop Mar, Guangzhou, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Huixian,Chen, Lingzhen,Zhang, Bo,et al. Molecular identification of GnIH and its potential role in reproductive physiology and male pregnancy of the lined seahorse (Hippocampus erectus)[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2019,279:196, 202.
APA Zhang, Huixian,Chen, Lingzhen,Zhang, Bo,&Lin, Qiang.(2019).Molecular identification of GnIH and its potential role in reproductive physiology and male pregnancy of the lined seahorse (Hippocampus erectus).GENERAL AND COMPARATIVE ENDOCRINOLOGY,279,196.
MLA Zhang, Huixian,et al."Molecular identification of GnIH and its potential role in reproductive physiology and male pregnancy of the lined seahorse (Hippocampus erectus)".GENERAL AND COMPARATIVE ENDOCRINOLOGY 279(2019):196.
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